Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류인균 | * |
dc.contributor.author | 윤수정 | * |
dc.contributor.author | 김정윤 | * |
dc.date.accessioned | 2021-11-10T16:30:55Z | - |
dc.date.available | 2021-11-10T16:30:55Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0022-3956 | * |
dc.identifier.issn | 1879-1379 | * |
dc.identifier.other | OAK-30220 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259258 | - |
dc.description.abstract | Background: Cytidine-5'-diphosphate choline (CDP-choline) has been suggested to exert neuroprotective and neuroreparative effects and may be beneficial for patients with stimulant dependence. This randomized, double-blind, placebo-controlled study in methamphetamine (MA) dependence investigated effects of CDP-choline on the brain structures and their associations with craving and MA use. Methods: MA users (n = 44) were randomized to receive 2 g/day of CDP-choline (n = 22) or placebo (n = 22) for 8 weeks. Patients underwent brain magnetic resonance imaging (MRI) at baseline and 8-week follow-up. Healthy individuals (n = 27) were also examined using brain MRI at the same interval. Voxel-based morphometry analysis was conducted to examine changes in gray matter (GM) volumes and their associations with craving and MA use. Results: Craving for MA was significantly reduced after the 8 week-treatment with CDP-choline (p = 0.01), but not with the placebo treatment (p = 0.10). There was no significant difference in the total number of MA-negative urine samples between the two groups (p = 0.19). With CDP-choline treatment, GM volumes in the left middle frontal gyrus (p = 0.001), right hippocampus (p = 0.009), and left precuneus (p = 0.001) were significantly increased compared to the placebo and control groups. Increased GM volumes in the left middle frontal gyrus with CDP-choline treatment were associated with reduced craving for MA (Spearman's rho = -0.56, p = 0.03). In addition, the right hippocampal volume increases were positively associated with the total number of MA-negative urine results in the CDP-choline group (Spearman's rho = 0.67, p = 0.006). Conclusion: Our findings suggest that CDP-choline may increase GM volumes of MA-dependent patients, which may be related to decreases in MA use and craving. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Cytidine-5 '-diphosphate choline | * |
dc.subject | Methamphetamine | * |
dc.subject | Magnetic resonance imaging | * |
dc.subject | Gray matter volume | * |
dc.title | Effects of cytidine-5 '-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study | * |
dc.type | Article | * |
dc.relation.volume | 143 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SSCI | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 215 | * |
dc.relation.lastpage | 221 | * |
dc.relation.journaltitle | JOURNAL OF PSYCHIATRIC RESEARCH | * |
dc.identifier.doi | 10.1016/j.jpsychires.2021.09.006 | * |
dc.identifier.wosid | WOS:000701669500006 | * |
dc.identifier.scopusid | 2-s2.0-85114445534 | * |
dc.author.google | Jeong, Hyeonseok | * |
dc.author.google | Yoon, Sujung | * |
dc.author.google | Sung, Young-Hoon | * |
dc.author.google | Kim, Jungyoon | * |
dc.author.google | Lyoo, In Kyoon | * |
dc.author.google | Yurgelun-Todd, Deborah A. | * |
dc.author.google | Renshaw, Perry F. | * |
dc.contributor.scopusid | 류인균(55664289900) | * |
dc.contributor.scopusid | 윤수정(15766754400) | * |
dc.contributor.scopusid | 김정윤(56993024200) | * |
dc.date.modifydate | 20240301081003 | * |