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Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042

Title
Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
Authors
Hong, AhreumNam, Sang-JipKo, JaeyoungYoon, JisooLee, Eun-SooLee, Eun-Young
Ewha Authors
남상집
SCOPUS Author ID
남상집scopusscopus
Issue Date
2020
Journal Title
MARINE DRUGS
ISSN
1660-3397JCR Link
Citation
MARINE DRUGS vol. 18, no. 9
Keywords
sarmentosamideStreptomyces sp.APmarine042anti-agingMMP-1UVBTNF-alpha
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derivedStreptomycessp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-alpha), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression.
DOI
10.3390/md18090463
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자연과학대학 > 화학·나노과학전공 > Journal papers
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