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Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
- Title
- Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
- Authors
- Lee, Eun-Soo; Lee, Eun-Young; Yoon, Jisoo; Hong, Ahreum; Nam, Sang-Jip; Ko, Jaeyoung
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2020
- Journal Title
- MARINE DRUGS
- ISSN
- 1660-3397
- Citation
- MARINE DRUGS vol. 18, no. 9
- Keywords
- sarmentosamide; Streptomyces sp.; APmarine042; anti-aging; MMP-1; UVB; TNF-alpha
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derivedStreptomycessp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-alpha), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression.
- DOI
- 10.3390/md18090463
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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