Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2021-09-15T16:32:13Z | - |
dc.date.available | 2021-09-15T16:32:13Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1660-3397 | * |
dc.identifier.other | OAK-28025 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259015 | - |
dc.description.abstract | Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derivedStreptomycessp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-alpha), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | sarmentosamide | * |
dc.subject | Streptomyces sp. | * |
dc.subject | APmarine042 | * |
dc.subject | anti-aging | * |
dc.subject | MMP-1 | * |
dc.subject | UVB | * |
dc.subject | TNF-alpha | * |
dc.title | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | MARINE DRUGS | * |
dc.identifier.doi | 10.3390/md18090463 | * |
dc.identifier.wosid | WOS:000580822300001 | * |
dc.identifier.scopusid | 2-s2.0-85091053769 | * |
dc.author.google | Lee, Eun-Soo | * |
dc.author.google | Lee, Eun-Young | * |
dc.author.google | Yoon, Jisoo | * |
dc.author.google | Hong, Ahreum | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Ko, Jaeyoung | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |