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Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice
- Title
- Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice
- Authors
- Park, Jiyoung; Lee, Eun Gyeong; Yi, Ho Jin; Kim, Nam Hee; Rhee, Sue Goo; Woo, Hyun Ae
- Ewha Authors
- 이은경; 우현애
- SCOPUS Author ID
- 이은경; 우현애
- Issue Date
- 2020
- Journal Title
- ANTIOXIDANTS
- ISSN
- 2076-3921
- Citation
- ANTIOXIDANTS vol. 9, no. 8
- Keywords
- peroxiredoxin V; reactive oxygen species; renal ischemia; reperfusion; renal dysfunction
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Ischemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the production and excessive accumulation of reactive oxygen species (ROS). Peroxiredoxin (Prx) V, a cysteine-dependent peroxidase, is located in the cytosol, mitochondria, and peroxisome and has an intensive ROS scavenging activity. Therefore, we focused on the role of Prx V during I/R-induced AKI using Prx V knockout (KO) mice. Ablation of Prx V augmented tubular damage, apoptosis, and declined renal function. Prx V deletion also showed higher susceptibility to I/R injury with increased markers for oxidative stress, ER stress, and inflammation in the kidney. Overall, these results demonstrate that Prx V protects the kidneys against I/R-induced injury.
- DOI
- 10.3390/antiox9080769
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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