Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이은경 | * |
dc.contributor.author | 우현애 | * |
dc.date.accessioned | 2021-01-14T16:30:24Z | - |
dc.date.available | 2021-01-14T16:30:24Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 2076-3921 | * |
dc.identifier.other | OAK-28017 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/256005 | - |
dc.description.abstract | Ischemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the production and excessive accumulation of reactive oxygen species (ROS). Peroxiredoxin (Prx) V, a cysteine-dependent peroxidase, is located in the cytosol, mitochondria, and peroxisome and has an intensive ROS scavenging activity. Therefore, we focused on the role of Prx V during I/R-induced AKI using Prx V knockout (KO) mice. Ablation of Prx V augmented tubular damage, apoptosis, and declined renal function. Prx V deletion also showed higher susceptibility to I/R injury with increased markers for oxidative stress, ER stress, and inflammation in the kidney. Overall, these results demonstrate that Prx V protects the kidneys against I/R-induced injury. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | peroxiredoxin V | * |
dc.subject | reactive oxygen species | * |
dc.subject | renal ischemia | * |
dc.subject | reperfusion | * |
dc.subject | renal dysfunction | * |
dc.title | Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | ANTIOXIDANTS | * |
dc.identifier.doi | 10.3390/antiox9080769 | * |
dc.identifier.wosid | WOS:000564605500001 | * |
dc.identifier.scopusid | 2-s2.0-85090813470 | * |
dc.author.google | Park, Jiyoung | * |
dc.author.google | Lee, Eun Gyeong | * |
dc.author.google | Yi, Ho Jin | * |
dc.author.google | Kim, Nam Hee | * |
dc.author.google | Rhee, Sue Goo | * |
dc.author.google | Woo, Hyun Ae | * |
dc.contributor.scopusid | 이은경(57218926598;39461667900) | * |
dc.contributor.scopusid | 우현애(8068619500) | * |
dc.date.modifydate | 20240301081003 | * |