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Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice

Title
Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice
Authors
Park, JiyoungLee, Eun GyeongYi, Ho JinKim, Nam HeeRhee, Sue GooWoo, Hyun Ae
Ewha Authors
이은경우현애
SCOPUS Author ID
이은경scopus; 우현애scopus
Issue Date
2020
Journal Title
ANTIOXIDANTS
ISSN
2076-3921JCR Link
Citation
ANTIOXIDANTS vol. 9, no. 8
Keywords
peroxiredoxin Vreactive oxygen speciesrenal ischemiareperfusionrenal dysfunction
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Ischemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the production and excessive accumulation of reactive oxygen species (ROS). Peroxiredoxin (Prx) V, a cysteine-dependent peroxidase, is located in the cytosol, mitochondria, and peroxisome and has an intensive ROS scavenging activity. Therefore, we focused on the role of Prx V during I/R-induced AKI using Prx V knockout (KO) mice. Ablation of Prx V augmented tubular damage, apoptosis, and declined renal function. Prx V deletion also showed higher susceptibility to I/R injury with increased markers for oxidative stress, ER stress, and inflammation in the kidney. Overall, these results demonstrate that Prx V protects the kidneys against I/R-induced injury.
DOI
10.3390/antiox9080769
Appears in Collections:
약학대학 > 약학과 > Journal papers
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