View : 471 Download: 54
Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients
- Title
- Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients
- Authors
- Im, Hee-Jin; Kim, Jee Hyun; Yun, Chang-Ho; Kim, Dong Wook; Oh, Jeeyoung
- Ewha Authors
- 김지현
- SCOPUS Author ID
- 김지현
- Issue Date
- 2020
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- ISSN
- 2077-0383
- Citation
- JOURNAL OF CLINICAL MEDICINE vol. 9, no. 12
- Keywords
- hepcidin; treatment response; restless legs syndrome; IRLS; quality of life
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Restless legs syndrome (RLS) is a common sensory motor neurological disorder that is related to iron-dopamine dysregulation and immune system alteration. We aimed to assess the effects of serum hepcidin, an iron-regulating hormone, in drug-naive RLS patients compared to healthy controls and to evaluate its role in helping to predict clinical improvement after treatment with dopamine agonist. Methods: Nonanemic and drug-naive RLS patients (n = 18) and healthy controls (n = 15) were enrolled. The serum hepcidin and iron-related values in the serum were measured upon the first visit in both groups and 12 weeks later after dopaminergic treatment in 12 patients. Information about sociodemographic characteristics, sleep-related profiles, mood and anxiety was obtained upon the first visit in all participants as well as after treatment in RLS patients. Results: Serum hepcidin levels exhibited no significant differences between patients with drug-naive RLS and healthy controls at diagnosis (7.1 +/- 2.4 vs. 7.0 +/- 3.2 ng/mL, p = 0.357). Decreased hepcidin levels were significantly associated with decreased RLS severity (beta = 0.002, 95% CI = 0.00-0.00, p = 0.005) and improved quality of life (beta = 0.002, 95% CI = 0.00-7.01, p = 0.044) in a dose-dependent manner after 12 weeks of treatment with a dopamine agonist. This association was independent of age, sex, inflammatory markers, sleep quality, insomnia, daytime sleepiness, depression and anxiety. Conclusions: This study demonstrates the role of hepcidin in evaluating the positive therapeutic response in RLS.
- DOI
- 10.3390/jcm9124115
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
- Files in This Item:
-
jcm-09-04115-v3.pdf(478.86 kB)
Download
- Export
- RIS (EndNote)
- XLS (Excel)
- XML