Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지현 | * |
dc.date.accessioned | 2021-01-14T16:30:12Z | - |
dc.date.available | 2021-01-14T16:30:12Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 2077-0383 | * |
dc.identifier.other | OAK-28598 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255936 | - |
dc.description.abstract | Background: Restless legs syndrome (RLS) is a common sensory motor neurological disorder that is related to iron-dopamine dysregulation and immune system alteration. We aimed to assess the effects of serum hepcidin, an iron-regulating hormone, in drug-naive RLS patients compared to healthy controls and to evaluate its role in helping to predict clinical improvement after treatment with dopamine agonist. Methods: Nonanemic and drug-naive RLS patients (n = 18) and healthy controls (n = 15) were enrolled. The serum hepcidin and iron-related values in the serum were measured upon the first visit in both groups and 12 weeks later after dopaminergic treatment in 12 patients. Information about sociodemographic characteristics, sleep-related profiles, mood and anxiety was obtained upon the first visit in all participants as well as after treatment in RLS patients. Results: Serum hepcidin levels exhibited no significant differences between patients with drug-naive RLS and healthy controls at diagnosis (7.1 +/- 2.4 vs. 7.0 +/- 3.2 ng/mL, p = 0.357). Decreased hepcidin levels were significantly associated with decreased RLS severity (beta = 0.002, 95% CI = 0.00-0.00, p = 0.005) and improved quality of life (beta = 0.002, 95% CI = 0.00-7.01, p = 0.044) in a dose-dependent manner after 12 weeks of treatment with a dopamine agonist. This association was independent of age, sex, inflammatory markers, sleep quality, insomnia, daytime sleepiness, depression and anxiety. Conclusions: This study demonstrates the role of hepcidin in evaluating the positive therapeutic response in RLS. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | hepcidin | * |
dc.subject | treatment response | * |
dc.subject | restless legs syndrome | * |
dc.subject | IRLS | * |
dc.subject | quality of life | * |
dc.title | Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | JOURNAL OF CLINICAL MEDICINE | * |
dc.identifier.doi | 10.3390/jcm9124115 | * |
dc.identifier.wosid | WOS:000601939500001 | * |
dc.author.google | Im, Hee-Jin | * |
dc.author.google | Kim, Jee Hyun | * |
dc.author.google | Yun, Chang-Ho | * |
dc.author.google | Kim, Dong Wook | * |
dc.author.google | Oh, Jeeyoung | * |
dc.contributor.scopusid | 김지현(55932113900) | * |
dc.date.modifydate | 20240315131236 | * |