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The Ventral Midline Thalamus Mediates Hippocampal Spatial Information Processes upon Spatial Cue Changes

Title
The Ventral Midline Thalamus Mediates Hippocampal Spatial Information Processes upon Spatial Cue Changes
Authors
Jung, DaheeHuh, YeowoolCho, Jeiwon
Ewha Authors
조제원
Issue Date
2019
Journal Title
JOURNAL OF NEUROSCIENCE
ISSN
0270-6474JCR Link
Citation
JOURNAL OF NEUROSCIENCE vol. 39, no. 12, pp. 2276 - 2290
Keywords
hippocampusnucleus reuniensobject locationplace cellsspatial informationventral midline thalamus
Publisher
SOC NEUROSCIENCE
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
The ventral midline thalamus, consisting of the reuniens and rhomboid nuclei (RE/Rh), is a thalamic structure interconnected with the limbic systems including the hippocampus. Recently, many studies have revealed that this structure plays distinctive roles in spatial learning and memory in collaboration with hippocampal functions. However, what aspects of spatial information process are influenced by the RE/Rh is not clearly known. To elucidate the roles of RE/Rh in spatial information processing and its effects on hippocampal activity, specifically with the manipulation of spatial contents, we measured hippocampal-dependent spatial memory performance and hippocampal place cell activities after RE/Rh lesion using male C57BL/6J x 129/SvJae hybrid mice. We found that the lesion altered the behavioral aptitude in recognizing locational changes of an object. Furthermore, CA1 place cells in the lesion group showed different spatial representation patterns in recognizing the environment with cue locational changes compared with the control group. Interestingly, the patterns of CA1 place cells in recognizing the same environment previously visited were not disrupted in the lesion group compared with the control group. These findings demonstrate that the ventral midline thalamus (RE/Rh) is important in recognizing the spatial relationships, especially when spatial rearrangement of cue position was introduced.
DOI
10.1523/JNEUROSCI.2127-18.2019
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
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