View : 180 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author조제원-
dc.date.accessioned2020-08-20T16:30:22Z-
dc.date.available2020-08-20T16:30:22Z-
dc.date.issued2019-
dc.identifier.issn0270-6474-
dc.identifier.otherOAK-27587-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/255061-
dc.description.abstractThe ventral midline thalamus, consisting of the reuniens and rhomboid nuclei (RE/Rh), is a thalamic structure interconnected with the limbic systems including the hippocampus. Recently, many studies have revealed that this structure plays distinctive roles in spatial learning and memory in collaboration with hippocampal functions. However, what aspects of spatial information process are influenced by the RE/Rh is not clearly known. To elucidate the roles of RE/Rh in spatial information processing and its effects on hippocampal activity, specifically with the manipulation of spatial contents, we measured hippocampal-dependent spatial memory performance and hippocampal place cell activities after RE/Rh lesion using male C57BL/6J x 129/SvJae hybrid mice. We found that the lesion altered the behavioral aptitude in recognizing locational changes of an object. Furthermore, CA1 place cells in the lesion group showed different spatial representation patterns in recognizing the environment with cue locational changes compared with the control group. Interestingly, the patterns of CA1 place cells in recognizing the same environment previously visited were not disrupted in the lesion group compared with the control group. These findings demonstrate that the ventral midline thalamus (RE/Rh) is important in recognizing the spatial relationships, especially when spatial rearrangement of cue position was introduced.-
dc.languageEnglish-
dc.publisherSOC NEUROSCIENCE-
dc.subjecthippocampus-
dc.subjectnucleus reuniens-
dc.subjectobject location-
dc.subjectplace cells-
dc.subjectspatial information-
dc.subjectventral midline thalamus-
dc.titleThe Ventral Midline Thalamus Mediates Hippocampal Spatial Information Processes upon Spatial Cue Changes-
dc.typeArticle-
dc.relation.issue12-
dc.relation.volume39-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2276-
dc.relation.lastpage2290-
dc.relation.journaltitleJOURNAL OF NEUROSCIENCE-
dc.identifier.doi10.1523/JNEUROSCI.2127-18.2019-
dc.identifier.wosidWOS:000461756300010-
dc.author.googleJung, Dahee-
dc.author.googleHuh, Yeowool-
dc.author.googleCho, Jeiwon-
dc.date.modifydate20200820161208-
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE