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Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice

Title
Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice
Authors
Lee J.-E.Kwon H.-J.Choi J.Seo J.-S.Han P.-L.
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2020
Journal Title
Communications Biology
ISSN
2399-3642JCR Link
Citation
Communications Biology vol. 3, no. 1
Publisher
Nature Research
Indexed
SCOPUS WOS scopus
Document Type
Article
Abstract
Brain aging proceeds with cellular and molecular changes in the limbic system. Aging-dependent changes might affect emotion and stress coping, yet the underlying mechanisms remain unclear. Here, we show aged (18-month-old) mice exhibit upregulation of NADPH oxidase and oxidative stress in the hippocampus, which mirrors the changes in young (2-month-old) mice subjected to chronic stress. Aged mice that lack p47phox, a key subunit of NADPH oxidase, do not show increased oxidative stress. Aged mice exhibit depression-like behavior following weak stress that does not produce depressive behavior in young mice. Aged mice have reduced expression of the epigenetic factor SUV39H1 and its upstream regulator p-AMPK, and increased expression of Ppp2ca in the hippocampus—changes that occur in young mice exposed to chronic stress. SUV39H1 mediates stress- and aging-induced sustained upregulation of p47phox and oxidative stress. These results suggest that aging increases susceptibility to stress by upregulating NADPH oxidase in the hippocampus. © 2020, The Author(s).
DOI
10.1038/s42003-020-1010-5
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
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