Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2020-07-10T16:30:11Z | - |
dc.date.available | 2020-07-10T16:30:11Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2399-3642 | - |
dc.identifier.other | OAK-27080 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254106 | - |
dc.description.abstract | Brain aging proceeds with cellular and molecular changes in the limbic system. Aging-dependent changes might affect emotion and stress coping, yet the underlying mechanisms remain unclear. Here, we show aged (18-month-old) mice exhibit upregulation of NADPH oxidase and oxidative stress in the hippocampus, which mirrors the changes in young (2-month-old) mice subjected to chronic stress. Aged mice that lack p47phox, a key subunit of NADPH oxidase, do not show increased oxidative stress. Aged mice exhibit depression-like behavior following weak stress that does not produce depressive behavior in young mice. Aged mice have reduced expression of the epigenetic factor SUV39H1 and its upstream regulator p-AMPK, and increased expression of Ppp2ca in the hippocampus—changes that occur in young mice exposed to chronic stress. SUV39H1 mediates stress- and aging-induced sustained upregulation of p47phox and oxidative stress. These results suggest that aging increases susceptibility to stress by upregulating NADPH oxidase in the hippocampus. © 2020, The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Research | - |
dc.title | Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 3 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Communications Biology | - |
dc.identifier.doi | 10.1038/s42003-020-1010-5 | - |
dc.identifier.wosid | WOS:000540512500002 | - |
dc.identifier.scopusid | 2-s2.0-85085984618 | - |
dc.author.google | Lee J.-E. | - |
dc.author.google | Kwon H.-J. | - |
dc.author.google | Choi J. | - |
dc.author.google | Seo J.-S. | - |
dc.author.google | Han P.-L. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |