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Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160
- Title
- Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160
- Authors
- Le, Tu Cam; Katila, Nikita; Park, Songhee; Lee, Jihye; Yang, Inho; Choi, Hyukjae; Choi, Dong-Young; Nam, Sang-Jip
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2020
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- ISSN
- 0960-894X
1464-3405
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 30, no. 11
- Keywords
- Saccharomonospora sp.; Marine natural products; Chlorinated secondary metabolites
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of beta-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of A beta (1-40) and A beta (1-42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression.
- DOI
- 10.1016/j.bmcl.2020.127145
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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