Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2020-05-04T16:30:09Z | - |
dc.date.available | 2020-05-04T16:30:09Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0960-894X | * |
dc.identifier.issn | 1464-3405 | * |
dc.identifier.other | OAK-26859 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253881 | - |
dc.description.abstract | Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of beta-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of A beta (1-40) and A beta (1-42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Saccharomonospora sp. | * |
dc.subject | Marine natural products | * |
dc.subject | Chlorinated secondary metabolites | * |
dc.title | Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160 | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | * |
dc.identifier.doi | 10.1016/j.bmcl.2020.127145 | * |
dc.identifier.wosid | WOS:000526087400027 | * |
dc.identifier.scopusid | 2-s2.0-85082794123 | * |
dc.author.google | Le, Tu Cam | * |
dc.author.google | Katila, Nikita | * |
dc.author.google | Park, Songhee | * |
dc.author.google | Lee, Jihye | * |
dc.author.google | Yang, Inho | * |
dc.author.google | Choi, Hyukjae | * |
dc.author.google | Choi, Dong-Young | * |
dc.author.google | Nam, Sang-Jip | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |