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Lobeglitazone and pioglitazone as add-ons to metformin for patients with type 2 diabetes: a 24-week, multicentre, randomized, double-blind, parallel-group, active-controlled, phase III clinical trial with a 28-week extension

Title
Lobeglitazone and pioglitazone as add-ons to metformin for patients with type 2 diabetes: a 24-week, multicentre, randomized, double-blind, parallel-group, active-controlled, phase III clinical trial with a 28-week extension
Authors
Jin, S-MPark, C-YCho, Y. M.Ku, B. J.Ahn, C. W.Cha, B-SMin, K. W.Sung, Y. A.Baik, S. H.Lee, K. W.Yoon, K-HLee, M-KPark, S. W.
Ewha Authors
성연아
SCOPUS Author ID
성연아scopus
Issue Date
2015
Journal Title
DIABETES OBESITY & METABOLISM
ISSN
1462-8902JCR Link

1463-1326JCR Link
Citation
DIABETES OBESITY & METABOLISM vol. 17, no. 6, pp. 599 - 602
Keywords
antidiabetic drugclinical trialphase III studyrandomised trialthiazolidinediones
Publisher
WILEY-BLACKWELL
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
We aimed to compare the efficacy and safety of lobeglitazone and pioglitazone as add-ons to metformin in patients with type 2 diabetes. Patients who were inadequately controlled by metformin were randomized and treated once daily with either lobeglitazone (0.5mg, n= 128) or pioglitazone (15 mg, n= 125) for 24weeks, with a 28-week extension trial of lobeglitazone treatment in patients who consented. The primary endpoint was the change in glycated haemoglobin (HbA1c) concentration from baseline to week 24. At week 24, the mean change from baseline in HbA1c was -0.74% for the lobeglitazone group and -0.74% for the pioglitazone group, with a mean difference of 0.01% [95% confidence interval (CI) of difference, -0.16 to 0.18]. The effects of lobeglitazone on lipid variables and the adverse events associated with lobeglitazone were similar to those observed with pioglitazone. Lobeglitazone was not inferior to pioglitazone as an add-on to metformin in terms of their efficacy and safety.
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DOI
10.1111/dom.12435
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의과대학 > 의학과 > Journal papers
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