View : 267 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author성연아-
dc.date.accessioned2019-11-14T16:31:42Z-
dc.date.available2019-11-14T16:31:42Z-
dc.date.issued2015-
dc.identifier.issn1462-8902-
dc.identifier.issn1463-1326-
dc.identifier.otherOAK-14869-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/251826-
dc.description.abstractWe aimed to compare the efficacy and safety of lobeglitazone and pioglitazone as add-ons to metformin in patients with type 2 diabetes. Patients who were inadequately controlled by metformin were randomized and treated once daily with either lobeglitazone (0.5mg, n= 128) or pioglitazone (15 mg, n= 125) for 24weeks, with a 28-week extension trial of lobeglitazone treatment in patients who consented. The primary endpoint was the change in glycated haemoglobin (HbA1c) concentration from baseline to week 24. At week 24, the mean change from baseline in HbA1c was -0.74% for the lobeglitazone group and -0.74% for the pioglitazone group, with a mean difference of 0.01% [95% confidence interval (CI) of difference, -0.16 to 0.18]. The effects of lobeglitazone on lipid variables and the adverse events associated with lobeglitazone were similar to those observed with pioglitazone. Lobeglitazone was not inferior to pioglitazone as an add-on to metformin in terms of their efficacy and safety.-
dc.languageEnglish-
dc.publisherWILEY-BLACKWELL-
dc.subjectantidiabetic drug-
dc.subjectclinical trial-
dc.subjectphase III study-
dc.subjectrandomised trial-
dc.subjectthiazolidinediones-
dc.titleLobeglitazone and pioglitazone as add-ons to metformin for patients with type 2 diabetes: a 24-week, multicentre, randomized, double-blind, parallel-group, active-controlled, phase III clinical trial with a 28-week extension-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume17-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage599-
dc.relation.lastpage602-
dc.relation.journaltitleDIABETES OBESITY & METABOLISM-
dc.identifier.doi10.1111/dom.12435-
dc.identifier.wosidWOS:000353765000011-
dc.identifier.scopusid2-s2.0-84928409354-
dc.author.googleJin, S-M-
dc.author.googlePark, C-Y-
dc.author.googleCho, Y. M.-
dc.author.googleKu, B. J.-
dc.author.googleAhn, C. W.-
dc.author.googleCha, B-S-
dc.author.googleMin, K. W.-
dc.author.googleSung, Y. A.-
dc.author.googleBaik, S. H.-
dc.author.googleLee, K. W.-
dc.author.googleYoon, K-H-
dc.author.googleLee, M-K-
dc.author.googlePark, S. W.-
dc.contributor.scopusid성연아(18435369300)-
dc.date.modifydate20191114141602-
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE