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Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid
- Title
- Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid
- Authors
- Zhang, Ying; Park, Jiyoung; Han, Seong-Jeong; Lim, Yongwoon; Park, Iha; Kim, Jong-Suk; Woo, Hyun Ae; Lee, Seung-Rock
- Ewha Authors
- 우현애
- SCOPUS Author ID
- 우현애
- Issue Date
- 2019
- Journal Title
- OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
- ISSN
- 1942-0900
1942-0994
- Citation
- OXIDATIVE MEDICINE AND CELLULAR LONGEVITY vol. 2019
- Publisher
- HINDAWI LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a lipid and protein phosphatase that coordinates various cellular processes. Its activity is regulated by the reversible oxidation of an active-site cysteine residue by H2O2 and thioredoxin. However, the potential role of lipid peroxides in the redox regulation of PTEN remains obscure. To evaluate this, 15-hydroperoxy-eicosatetraenoic acid (15s-HpETE), a lipid peroxide, was employed to investigate its effect on PTEN using molecular and cellular-based assays. Exposure to 15s-HpETE resulted in the oxidation of recombinant PTEN. Reversible oxidation of PTEN was also observed in mouse embryonic fibroblast (MEF) cells treated with a 15s-HpETE and Lipofectamine mixture. The oxidative dimerization of thioredoxin was found simultaneously. In addition, the absence of peroxiredoxin III aggravated 15s-HpETE-induced PTEN oxidation in MEF cells. Our study provides novel insight into the mechanism linking lipid peroxidation to the etiology of tumorigenesis.
- DOI
- 10.1155/2019/2828493
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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Peroxiredoxin III Protects Tumor Suppressor PTEN.pdf(1.99 MB)
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