Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 우현애 | * |
dc.date.accessioned | 2019-11-05T16:30:10Z | - |
dc.date.available | 2019-11-05T16:30:10Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1942-0900 | * |
dc.identifier.issn | 1942-0994 | * |
dc.identifier.other | OAK-25591 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251755 | - |
dc.description.abstract | Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a lipid and protein phosphatase that coordinates various cellular processes. Its activity is regulated by the reversible oxidation of an active-site cysteine residue by H2O2 and thioredoxin. However, the potential role of lipid peroxides in the redox regulation of PTEN remains obscure. To evaluate this, 15-hydroperoxy-eicosatetraenoic acid (15s-HpETE), a lipid peroxide, was employed to investigate its effect on PTEN using molecular and cellular-based assays. Exposure to 15s-HpETE resulted in the oxidation of recombinant PTEN. Reversible oxidation of PTEN was also observed in mouse embryonic fibroblast (MEF) cells treated with a 15s-HpETE and Lipofectamine mixture. The oxidative dimerization of thioredoxin was found simultaneously. In addition, the absence of peroxiredoxin III aggravated 15s-HpETE-induced PTEN oxidation in MEF cells. Our study provides novel insight into the mechanism linking lipid peroxidation to the etiology of tumorigenesis. | * |
dc.language | English | * |
dc.publisher | HINDAWI LTD | * |
dc.title | Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid | * |
dc.type | Article | * |
dc.relation.volume | 2019 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | * |
dc.identifier.doi | 10.1155/2019/2828493 | * |
dc.identifier.wosid | WOS:000488457000001 | * |
dc.author.google | Zhang, Ying | * |
dc.author.google | Park, Jiyoung | * |
dc.author.google | Han, Seong-Jeong | * |
dc.author.google | Lim, Yongwoon | * |
dc.author.google | Park, Iha | * |
dc.author.google | Kim, Jong-Suk | * |
dc.author.google | Woo, Hyun Ae | * |
dc.author.google | Lee, Seung-Rock | * |
dc.contributor.scopusid | 우현애(8068619500) | * |
dc.date.modifydate | 20240215164922 | * |