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약학대학
약학과
Journal papers
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Causes of hyperhomocysteinemia and its pathological significance
Title
Causes of hyperhomocysteinemia and its pathological significance
Authors
Kim J.
;
Kim H.
;
Roh H.
;
Kwon Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주
Issue Date
2018
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269
Citation
Archives of Pharmacal Research vol. 41, no. 4, pp. 372 - 383
Keywords
Disease caused by hyperhomocysteinemia
;
Homocysteine
;
Hyperhomocysteinemia
Publisher
Pharmaceutical Society of Korea
Indexed
SCIE; SCOPUS; KCI
Document Type
Review
Abstract
In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases. Homocysteine is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia is a state in which too much homocysteine is present in the body. The main cause of hyperhomocysteinemia is a dysfunction of enzymes and cofactors associated with the process of homocysteine biosynthesis. Other causes include excessive methionine intake, certain diseases and side effects of some drugs. Hyperhomocysteinemia is a trigger for many diseases, such as atherosclerosis, congestive heart failure, age-related macular degeneration, Alzheimer’s disease and hearing loss. There are many studies showing a positive relationship between homocysteine level and various symptoms. We speculate that a high level of homocysteine can be the sole reason or an aggravating factor in numerous diseases for which causal links are not fully understood. © 2018, The Pharmaceutical Society of Korea.
DOI
10.1007/s12272-018-1016-4
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