Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2018-12-14T16:31:05Z | - |
dc.date.available | 2018-12-14T16:31:05Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-22501 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247805 | - |
dc.description.abstract | In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases. Homocysteine is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia is a state in which too much homocysteine is present in the body. The main cause of hyperhomocysteinemia is a dysfunction of enzymes and cofactors associated with the process of homocysteine biosynthesis. Other causes include excessive methionine intake, certain diseases and side effects of some drugs. Hyperhomocysteinemia is a trigger for many diseases, such as atherosclerosis, congestive heart failure, age-related macular degeneration, Alzheimer’s disease and hearing loss. There are many studies showing a positive relationship between homocysteine level and various symptoms. We speculate that a high level of homocysteine can be the sole reason or an aggravating factor in numerous diseases for which causal links are not fully understood. © 2018, The Pharmaceutical Society of Korea. | * |
dc.language | English | * |
dc.publisher | Pharmaceutical Society of Korea | * |
dc.subject | Disease caused by hyperhomocysteinemia | * |
dc.subject | Homocysteine | * |
dc.subject | Hyperhomocysteinemia | * |
dc.title | Causes of hyperhomocysteinemia and its pathological significance | * |
dc.type | Review | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 41 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 372 | * |
dc.relation.lastpage | 383 | * |
dc.relation.journaltitle | Archives of Pharmacal Research | * |
dc.identifier.doi | 10.1007/s12272-018-1016-4 | * |
dc.identifier.wosid | WOS:000430869800002 | * |
dc.identifier.scopusid | 2-s2.0-85044033066 | * |
dc.author.google | Kim J. | * |
dc.author.google | Kim H. | * |
dc.author.google | Roh H. | * |
dc.author.google | Kwon Y. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |