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Potent selective inhibition of monoamine oxidase a by alternariol monomethyl ether isolated from alternaria brassicae
- Title
- Potent selective inhibition of monoamine oxidase a by alternariol monomethyl ether isolated from alternaria brassicae
- Authors
- Lee H.W.; Kim Y.J.; Nam S.-J.; Kim H.
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2017
- Journal Title
- Journal of Microbiology and Biotechnology
- ISSN
- 1017-7825
- Citation
- Journal of Microbiology and Biotechnology vol. 27, no. 2, pp. 316 - 320
- Keywords
- Alternaria brassicae; Alternariol monomethyl ether; Mixed inhibition; Monoamine oxidase; Selective inhibitor
- Publisher
- Korean Society for Microbiolog and Biotechnology
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Alternariol monomethyl ether (AME), a dibenzopyrone derivative, was isolated from Alternaria brassicae along with altertoxin II (ATX-II). The compounds were tested for the inhibitory activity of monoamine oxidase (MAO), which catalyzes neurotransmitting monoamines. AME was found to be a highly potent and selective inhibitor of human MAO-A with an IC50 value of 1.71 µM; however, it was found to be ineffective for MAO-B inhibition. ATX-II was not effective for the inhibition of either MAO-A or MAO-B. The inhibition of MAO-A using AME was apparently instantaneous. MAO-A activity was almost completely recovered after the dilution of the inhibited enzyme with an excess amount of AME, suggesting AME is a reversible inhibitor. AME showed mixed inhibition for MAO-A in Lineweaver-Burk plots with a Ki value of 0.34 µM. The findings of this study suggest that microbial metabolites and dibenzopyronei could be potent MAO inhibitors. In addition, AME could be a useful lead compound for developing reversible MAO-A inhibitors to treat depression, Parkinson’s disease, and Alzheimer’s disease. © 2017 by The Korean Society for Microbiology and Biotechnology.
- DOI
- 10.4014/jmb.1610.10053
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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