View : 216 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author남상집-
dc.date.accessioned2018-12-07T16:30:51Z-
dc.date.available2018-12-07T16:30:51Z-
dc.date.issued2017-
dc.identifier.issn1017-7825-
dc.identifier.otherOAK-20487-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/247450-
dc.description.abstractAlternariol monomethyl ether (AME), a dibenzopyrone derivative, was isolated from Alternaria brassicae along with altertoxin II (ATX-II). The compounds were tested for the inhibitory activity of monoamine oxidase (MAO), which catalyzes neurotransmitting monoamines. AME was found to be a highly potent and selective inhibitor of human MAO-A with an IC50 value of 1.71 µM; however, it was found to be ineffective for MAO-B inhibition. ATX-II was not effective for the inhibition of either MAO-A or MAO-B. The inhibition of MAO-A using AME was apparently instantaneous. MAO-A activity was almost completely recovered after the dilution of the inhibited enzyme with an excess amount of AME, suggesting AME is a reversible inhibitor. AME showed mixed inhibition for MAO-A in Lineweaver-Burk plots with a Ki value of 0.34 µM. The findings of this study suggest that microbial metabolites and dibenzopyronei could be potent MAO inhibitors. In addition, AME could be a useful lead compound for developing reversible MAO-A inhibitors to treat depression, Parkinson’s disease, and Alzheimer’s disease. © 2017 by The Korean Society for Microbiology and Biotechnology.-
dc.languageEnglish-
dc.publisherKorean Society for Microbiolog and Biotechnology-
dc.subjectAlternaria brassicae-
dc.subjectAlternariol monomethyl ether-
dc.subjectMixed inhibition-
dc.subjectMonoamine oxidase-
dc.subjectSelective inhibitor-
dc.titlePotent selective inhibition of monoamine oxidase a by alternariol monomethyl ether isolated from alternaria brassicae-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume27-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage316-
dc.relation.lastpage320-
dc.relation.journaltitleJournal of Microbiology and Biotechnology-
dc.identifier.doi10.4014/jmb.1610.10053-
dc.identifier.wosidWOS:000397168300013-
dc.identifier.scopusid2-s2.0-85014396078-
dc.author.googleLee H.W.-
dc.author.googleKim Y.J.-
dc.author.googleNam S.-J.-
dc.author.googleKim H.-
dc.contributor.scopusid남상집(57208839798;36455982300)-
dc.date.modifydate20210915112221-
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE