Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2018-12-07T16:30:51Z | - |
dc.date.available | 2018-12-07T16:30:51Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1017-7825 | * |
dc.identifier.other | OAK-20487 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247450 | - |
dc.description.abstract | Alternariol monomethyl ether (AME), a dibenzopyrone derivative, was isolated from Alternaria brassicae along with altertoxin II (ATX-II). The compounds were tested for the inhibitory activity of monoamine oxidase (MAO), which catalyzes neurotransmitting monoamines. AME was found to be a highly potent and selective inhibitor of human MAO-A with an IC50 value of 1.71 µM; however, it was found to be ineffective for MAO-B inhibition. ATX-II was not effective for the inhibition of either MAO-A or MAO-B. The inhibition of MAO-A using AME was apparently instantaneous. MAO-A activity was almost completely recovered after the dilution of the inhibited enzyme with an excess amount of AME, suggesting AME is a reversible inhibitor. AME showed mixed inhibition for MAO-A in Lineweaver-Burk plots with a Ki value of 0.34 µM. The findings of this study suggest that microbial metabolites and dibenzopyronei could be potent MAO inhibitors. In addition, AME could be a useful lead compound for developing reversible MAO-A inhibitors to treat depression, Parkinson’s disease, and Alzheimer’s disease. © 2017 by The Korean Society for Microbiology and Biotechnology. | * |
dc.language | English | * |
dc.publisher | Korean Society for Microbiolog and Biotechnology | * |
dc.subject | Alternaria brassicae | * |
dc.subject | Alternariol monomethyl ether | * |
dc.subject | Mixed inhibition | * |
dc.subject | Monoamine oxidase | * |
dc.subject | Selective inhibitor | * |
dc.title | Potent selective inhibition of monoamine oxidase a by alternariol monomethyl ether isolated from alternaria brassicae | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 316 | * |
dc.relation.lastpage | 320 | * |
dc.relation.journaltitle | Journal of Microbiology and Biotechnology | * |
dc.identifier.doi | 10.4014/jmb.1610.10053 | * |
dc.identifier.wosid | WOS:000397168300013 | * |
dc.identifier.scopusid | 2-s2.0-85014396078 | * |
dc.author.google | Lee H.W. | * |
dc.author.google | Kim Y.J. | * |
dc.author.google | Nam S.-J. | * |
dc.author.google | Kim H. | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |