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Two new naphthalenic lactone glycosides from Cassia obtusifolia L. seeds
- Title
- Two new naphthalenic lactone glycosides from Cassia obtusifolia L. seeds
- Authors
- Shrestha, Srijan; Paudel, Pradeep; Seong, Su Hui; Min, Byung Sun; Seo, Eun Kyoung; Jung, Hyun Ah; Choi, Jae Sue
- Ewha Authors
- 서은경
- SCOPUS Author ID
- 서은경
- Issue Date
- 2018
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- ISSN
- 0253-6269
1976-3786
- Citation
- ARCHIVES OF PHARMACAL RESEARCH vol. 41, no. 7, pp. 737 - 742
- Keywords
- Cassia obtusifolia; Naphthalenic lactone glycosides; Advanced glycation end-products
- Publisher
- PHARMACEUTICAL SOC KOREA
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Two new naphthalenic lactone glycosides, (3S)-9,10-dihydroxy-7-methoxy-3-methyl-1-oxo-3,4-dihydro-1H-benzo[g]isochromene-3-carboxylic acid 9-O-beta-d-glucopyranoside (1) and (3R)-cassialactone 9-O-beta-d-glucopyranoside (2) were isolated from seeds of Cassia obtusifolia Linn., along with five known compounds: (3R)-cassialactone 9-O-beta-d-gentiobioside (3), emodin 1-O-beta-gentiobioside (4), 1-hydroxyl-2-acetyl-3,8-dimethoxy-naphthalene 6-O-beta-d-apiofuranosyl-(1 -> 2)-beta-d-glucopyranoside (5), rubrofusarin 6-O-beta-d-gentiobioside (6), rubrofusarin 6-O-beta-d-triglucoside (7). Structures of 1 and 2 were elucidated by NMR and HR-ESI-MS spectroscopic analysis. Their stereochemistry was determined by CD experiment. All compounds were tested for their ability to inhibit the formation of advanced glycation end-products in vitro. Compounds 1, 2, 3, 5, and 6 showed significant in vitro inhibitory activities (IC50 values of 11.63, 23.40, 7.32, 89.03, and 38.89 A mu M, respectively).
- DOI
- 10.1007/s12272-018-1044-0
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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