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DNA strand-nicking principles of Mucuna birdwoodiana

Title
DNA strand-nicking principles of Mucuna birdwoodiana
Authors
Han A.-R.Mar W.Seo E.-K.
Ewha Authors
서은경한아름
SCOPUS Author ID
서은경scopus; 한아름scopus
Issue Date
2003
Journal Title
Natural Product Sciences
ISSN
1226-3907JCR Link
Citation
Natural Product Sciences vol. 9, no. 2, pp. 105 - 108
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
During our research program to find DNA strand-scission agents from higher plants, the MeOH extracts of the stems of Mucuna birdwoodiana Tutcher. (Leguminosae) exhibited the most potent activity with an IC50 value of 4.9 μg/ml. Thus, detailed laboratory investigation was performed, and led to the isolation of known compounds, (±)-catechin (1) and (-)-epicatechin (2) as active principles. Compounds 1 and 2 showed significant activity of DNA strand-scission with IC50 values of 10.8 and 7.5 μg/ml, respectively (positive control, bleomycin: IC50 3.3 μg/ml).
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약학대학 > 약학과 > Journal papers
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