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자연과학대학
화학·나노과학전공
Journal papers
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Injectable gel: Poly(ethylene glycol)-sebacic acid polyester
Title
Injectable gel: Poly(ethylene glycol)-sebacic acid polyester
Authors
Lee J.
;
Joo M.K.
;
Oh H.
;
Sohn Y.S.
;
Jeong B.
Ewha Authors
손연수
;
정병문
SCOPUS Author ID
손연수
; 정병문
Issue Date
2006
Journal Title
Polymer
ISSN
0032-3861
Citation
Polymer vol. 47, no. 11, pp. 3760 - 3766
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)-sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes 'clear sol-to-gel' transition as the temperature increases from 5 to 65 °C. The drug can be mixed in a low viscous sol state at low temperature (<15 °C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC-dextran (molecular weight: 40,000 Da), was released from the gel over 24 h. The biodegradable poly(ethylene glycol)-sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern. © 2006 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.polymer.2006.03.109
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