Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손연수 | * |
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2018-05-30T08:13:53Z | - |
dc.date.available | 2018-05-30T08:13:53Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0032-3861 | * |
dc.identifier.other | OAK-3392 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243425 | - |
dc.description.abstract | In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)-sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes 'clear sol-to-gel' transition as the temperature increases from 5 to 65 °C. The drug can be mixed in a low viscous sol state at low temperature (<15 °C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC-dextran (molecular weight: 40,000 Da), was released from the gel over 24 h. The biodegradable poly(ethylene glycol)-sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern. © 2006 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Injectable gel: Poly(ethylene glycol)-sebacic acid polyester | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 47 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3760 | * |
dc.relation.lastpage | 3766 | * |
dc.relation.journaltitle | Polymer | * |
dc.identifier.doi | 10.1016/j.polymer.2006.03.109 | * |
dc.identifier.wosid | WOS:000238366200009 | * |
dc.identifier.scopusid | 2-s2.0-33646821047 | * |
dc.author.google | Lee J. | * |
dc.author.google | Joo M.K. | * |
dc.author.google | Oh H. | * |
dc.author.google | Sohn Y.S. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 손연수(7201971323) | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |