Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오만숙 | * |
dc.contributor.author | 신동완 | * |
dc.contributor.author | 강승호 | * |
dc.date.accessioned | 2018-05-30T08:13:51Z | - |
dc.date.available | 2018-05-30T08:13:51Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0323-3847 | * |
dc.identifier.other | OAK-3420 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243407 | - |
dc.description.abstract | A Bayesian model-based clustering approach is proposed for identifying differentially expressed genes in meta-analysis. A Bayesian hierarchical model is used as a scientific tool for combining information from different studies, and a mixture prior is used to separate differentially expressed genes from non-differentially expressed genes. Posterior estimation of the parameters and missing observations are done by using a simple Markov chain Monte Carlo method. From the estimated mixture model, useful measure of significance of a test such as the Bayesian false discovery rate (FDR), the local FDR (Efron et al., 2001), and the integration-driven discovery rate (IDR; Choi et al., 2003) can be easily computed. The model-based approach is also compared with commonly used permutation methods, and it is shown that the model-based approach is superior to the permutation methods when there are excessive under-expressed genes compared to over-expressed genes or vice versa. The proposed method is applied to four publicly available prostate cancer gene expression data sets and simulated data sets. © 2006 WILEY-VCH Verlag GmbH & Co. KGaA. | * |
dc.language | English | * |
dc.title | Identifying differentially expressed genes in meta-analysis via Bayesian model-based clustering | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 48 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 435 | * |
dc.relation.lastpage | 450 | * |
dc.relation.journaltitle | Biometrical Journal | * |
dc.identifier.doi | 10.1002/bimj.200410230 | * |
dc.identifier.wosid | WOS:000238768100009 | * |
dc.identifier.scopusid | 2-s2.0-33745654577 | * |
dc.author.google | Jung Y.-Y. | * |
dc.author.google | Oh M.-S. | * |
dc.author.google | Shin D.W. | * |
dc.author.google | Kang S.-Ho. | * |
dc.author.google | Oh H.S. | * |
dc.contributor.scopusid | 오만숙(7201600334) | * |
dc.contributor.scopusid | 신동완(7403352539) | * |
dc.contributor.scopusid | 강승호(7405663992) | * |
dc.date.modifydate | 20240116115756 | * |