View : 800 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author이승록-
dc.date.accessioned2018-05-02T08:15:41Z-
dc.date.available2018-05-02T08:15:41Z-
dc.date.issued2004-
dc.identifier.issn0304-3835-
dc.identifier.otherOAK-2164-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/242772-
dc.description.abstractTumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on the surface of endothelial cells. From the screening of medicinal plants, we have identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from the roots of Paeonia lactiflora that inhibited the binding of VEGF to KDR/Flk-1. PGG efficiently blocked VEGF-induced human umbilical vein endothelial cell proliferation and the growth of immortalized human microvascular endothelial cells, but did not affect the growth of HT1080 human fibrosarcoma and DU-145 human prostate carcinoma cells. PGG also blocked VEGF-induced capillary-like tube formation of endothelial cell on Matrigel. Our results suggest that PGG could be a candidate for developing anti-angiogenic agent. © 2003 Elsevier Ireland Ltd. All rights reserved.-
dc.languageEnglish-
dc.title1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume208-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage89-
dc.relation.lastpage94-
dc.relation.journaltitleCancer Letters-
dc.identifier.doi10.1016/j.canlet.2003.11.008-
dc.identifier.wosidWOS:000221369000009-
dc.identifier.scopusid2-s2.0-16544364669-
dc.author.googleLee S.-J.-
dc.author.googleLee H.M.-
dc.author.googleJi S.-T.-
dc.author.googleLee S.-R.-
dc.author.googleMar W.-
dc.author.googleGho Y.S.-
dc.date.modifydate20200911081002-
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE