Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승록 | - |
dc.date.accessioned | 2018-05-02T08:15:41Z | - |
dc.date.available | 2018-05-02T08:15:41Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | OAK-2164 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242772 | - |
dc.description.abstract | Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on the surface of endothelial cells. From the screening of medicinal plants, we have identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from the roots of Paeonia lactiflora that inhibited the binding of VEGF to KDR/Flk-1. PGG efficiently blocked VEGF-induced human umbilical vein endothelial cell proliferation and the growth of immortalized human microvascular endothelial cells, but did not affect the growth of HT1080 human fibrosarcoma and DU-145 human prostate carcinoma cells. PGG also blocked VEGF-induced capillary-like tube formation of endothelial cell on Matrigel. Our results suggest that PGG could be a candidate for developing anti-angiogenic agent. © 2003 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 208 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 89 | - |
dc.relation.lastpage | 94 | - |
dc.relation.journaltitle | Cancer Letters | - |
dc.identifier.doi | 10.1016/j.canlet.2003.11.008 | - |
dc.identifier.wosid | WOS:000221369000009 | - |
dc.identifier.scopusid | 2-s2.0-16544364669 | - |
dc.author.google | Lee S.-J. | - |
dc.author.google | Lee H.M. | - |
dc.author.google | Ji S.-T. | - |
dc.author.google | Lee S.-R. | - |
dc.author.google | Mar W. | - |
dc.author.google | Gho Y.S. | - |
dc.contributor.scopusid | 이승록(7409773214) | - |
dc.date.modifydate | 20211210152212 | - |