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1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor
- Title
- 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor
- Authors
- Lee S.-J.; Lee H.M.; Ji S.-T.; Lee S.-R.; Mar W.; Gho Y.S.
- Ewha Authors
- 이승록
- SCOPUS Author ID
- 이승록
- Issue Date
- 2004
- Journal Title
- Cancer Letters
- ISSN
- 0304-3835
- Citation
- Cancer Letters vol. 208, no. 1, pp. 89 - 94
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on the surface of endothelial cells. From the screening of medicinal plants, we have identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from the roots of Paeonia lactiflora that inhibited the binding of VEGF to KDR/Flk-1. PGG efficiently blocked VEGF-induced human umbilical vein endothelial cell proliferation and the growth of immortalized human microvascular endothelial cells, but did not affect the growth of HT1080 human fibrosarcoma and DU-145 human prostate carcinoma cells. PGG also blocked VEGF-induced capillary-like tube formation of endothelial cell on Matrigel. Our results suggest that PGG could be a candidate for developing anti-angiogenic agent. © 2003 Elsevier Ireland Ltd. All rights reserved.
- DOI
- 10.1016/j.canlet.2003.11.008
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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