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Evaluation of Ki-67 Index in Core Needle Biopsies and Matched Breast Cancer Surgical Specimens

Title
Evaluation of Ki-67 Index in Core Needle Biopsies and Matched Breast Cancer Surgical Specimens
Authors
Ahn, SoominLee, JunghyeCho, Min-SunPark, SanghuiSung, Sun Hee
Ewha Authors
성순희조민선박상희
SCOPUS Author ID
성순희scopus; 조민선scopus; 박상희scopus
Issue Date
2018
Journal Title
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
ISSN
0003-9985JCR Link

1543-2165JCR Link
Citation
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE vol. 142, no. 3, pp. 364 - 368
Publisher
COLL AMER PATHOLOGISTS
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Context.-The Ki-67 index is strongly prognostic and is used as a surrogate marker to distinguish luminal A from luminal B breast cancer types. Objective.-To investigate differences in Ki-67 index between core needle biopsy samples and matched surgical samples in breast cancer. Design.-We included patients with invasive breast cancer who did not receive neoadjuvant therapy. A total of 89 pairs of core needle biopsies and surgical specimens were collected, and the Ki-67 index was assessed in hot spot areas using an image analyzer. We applied a 14% Ki-67 index to define low versus high groups. Results.-The Ki-67 index was significantly higher in core needle biopsies than in surgical specimens (P < 001), with a median absolute difference of 3.5%. When we applied 14% as a cutoff, 16 of 89 cases (18%) showed discrepancy. Thirteen cases showed a high Ki-67 index in core needle biopsies but a low Ki-67 index in surgical samples. There were 10 cases (11.2%) that showed discordant luminal A/B types between core needle biopsy and the matched surgical specimen. The reasons for the discordance were poor staining of MIB1 accompanied by fixation issues and intratumoral heterogeneity of the Ki-67 index. Conclusions.-A significant difference in the Ki-67 index between core biopsy and surgical specimens was observed. Our findings indicate that it may be better to perform the Ki-67 assay on the core needle biopsy and the surgical specimen than on only one sample.
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DOI
10.5858/arpa.2017-0014-OA
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의과대학 > 의학과 > Journal papers
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