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dc.contributor.author성순희-
dc.contributor.author조민선-
dc.contributor.author박상희-
dc.date.accessioned2018-04-25T08:13:21Z-
dc.date.available2018-04-25T08:13:21Z-
dc.date.issued2018-
dc.identifier.issn0003-9985-
dc.identifier.issn1543-2165-
dc.identifier.otherOAK-22181-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/242465-
dc.description.abstractContext.-The Ki-67 index is strongly prognostic and is used as a surrogate marker to distinguish luminal A from luminal B breast cancer types. Objective.-To investigate differences in Ki-67 index between core needle biopsy samples and matched surgical samples in breast cancer. Design.-We included patients with invasive breast cancer who did not receive neoadjuvant therapy. A total of 89 pairs of core needle biopsies and surgical specimens were collected, and the Ki-67 index was assessed in hot spot areas using an image analyzer. We applied a 14% Ki-67 index to define low versus high groups. Results.-The Ki-67 index was significantly higher in core needle biopsies than in surgical specimens (P < 001), with a median absolute difference of 3.5%. When we applied 14% as a cutoff, 16 of 89 cases (18%) showed discrepancy. Thirteen cases showed a high Ki-67 index in core needle biopsies but a low Ki-67 index in surgical samples. There were 10 cases (11.2%) that showed discordant luminal A/B types between core needle biopsy and the matched surgical specimen. The reasons for the discordance were poor staining of MIB1 accompanied by fixation issues and intratumoral heterogeneity of the Ki-67 index. Conclusions.-A significant difference in the Ki-67 index between core biopsy and surgical specimens was observed. Our findings indicate that it may be better to perform the Ki-67 assay on the core needle biopsy and the surgical specimen than on only one sample.-
dc.languageEnglish-
dc.publisherCOLL AMER PATHOLOGISTS-
dc.titleEvaluation of Ki-67 Index in Core Needle Biopsies and Matched Breast Cancer Surgical Specimens-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume142-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage364-
dc.relation.lastpage368-
dc.relation.journaltitleARCHIVES OF PATHOLOGY & LABORATORY MEDICINE-
dc.identifier.doi10.5858/arpa.2017-0014-OA-
dc.identifier.wosidWOS:000427446300012-
dc.identifier.scopusid2-s2.0-85042639140-
dc.author.googleAhn, Soomin-
dc.author.googleLee, Junghye-
dc.author.googleCho, Min-Sun-
dc.author.googlePark, Sanghui-
dc.author.googleSung, Sun Hee-
dc.contributor.scopusid성순희(7202731948)-
dc.contributor.scopusid조민선(13205279200)-
dc.contributor.scopusid박상희(12041890800)-
dc.date.modifydate20210915163347-
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의과대학 > 의학과 > Journal papers
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