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A commensal strain of Staphylococcus epidermidis protects against skin neoplasia
- Title
- A commensal strain of Staphylococcus epidermidis protects against skin neoplasia
- Authors
- Nakatsuji, Teruaki; Chen, Tiffany H.; Butcher, Anna M.; Trzoss, Lynnie L.; Nam, Sang-Jip; Shirakawa, Karina T.; Zhou, Wei; Oh, Julia; Otto, Michael; Fenical, William; Gallo, Richard L.
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2018
- Journal Title
- SCIENCE ADVANCES
- ISSN
- 2375-2548
- Citation
- SCIENCE ADVANCES vol. 4, no. 2
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Indexed
- SCOPUS
- Document Type
- Article
- Abstract
- We report the discovery that strains of Staphylococcus epidermidis produce 6-N-hydroxyaminopurine ( 6-HAP), a molecule that inhibits DNA polymerase activity. In culture, 6-HAP selectively inhibited proliferation of tumor lines but did not inhibit primary keratinocytes. Resistance to 6-HAP was associated with the expression of mitochondrial amidoxime reducing components, enzymes that were not observed in cells sensitive to this compound. Intravenous injection of 6-HAP in mice suppressed the growth of B16F10 melanoma without evidence of systemic toxicity. Colonization of mice with an S. epidermidis strain producing 6-HAP reduced the incidence of ultraviolet-induced tumors compared to mice colonized by a control strain that did not produce 6-HAP. S. epidermidis strains producing 6-HAP were found in the metagenome from multiple healthy human subjects, suggesting that the microbiome of some individuals may confer protection against skin cancer. These findings show a new role for skin commensal bacteria in host defense.
- DOI
- 10.1126/sciadv.aao4502
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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