Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2018-04-25T08:13:12Z | - |
dc.date.available | 2018-04-25T08:13:12Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 2375-2548 | * |
dc.identifier.other | OAK-22287 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242411 | - |
dc.description.abstract | We report the discovery that strains of Staphylococcus epidermidis produce 6-N-hydroxyaminopurine ( 6-HAP), a molecule that inhibits DNA polymerase activity. In culture, 6-HAP selectively inhibited proliferation of tumor lines but did not inhibit primary keratinocytes. Resistance to 6-HAP was associated with the expression of mitochondrial amidoxime reducing components, enzymes that were not observed in cells sensitive to this compound. Intravenous injection of 6-HAP in mice suppressed the growth of B16F10 melanoma without evidence of systemic toxicity. Colonization of mice with an S. epidermidis strain producing 6-HAP reduced the incidence of ultraviolet-induced tumors compared to mice colonized by a control strain that did not produce 6-HAP. S. epidermidis strains producing 6-HAP were found in the metagenome from multiple healthy human subjects, suggesting that the microbiome of some individuals may confer protection against skin cancer. These findings show a new role for skin commensal bacteria in host defense. | * |
dc.language | English | * |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | * |
dc.title | A commensal strain of Staphylococcus epidermidis protects against skin neoplasia | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 4 | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | SCIENCE ADVANCES | * |
dc.identifier.doi | 10.1126/sciadv.aao4502 | * |
dc.identifier.wosid | WOS:000426845500032 | * |
dc.identifier.scopusid | 2-s2.0-85044778931 | * |
dc.author.google | Nakatsuji, Teruaki | * |
dc.author.google | Chen, Tiffany H. | * |
dc.author.google | Butcher, Anna M. | * |
dc.author.google | Trzoss, Lynnie L. | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Shirakawa, Karina T. | * |
dc.author.google | Zhou, Wei | * |
dc.author.google | Oh, Julia | * |
dc.author.google | Otto, Michael | * |
dc.author.google | Fenical, William | * |
dc.author.google | Gallo, Richard L. | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |