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자연과학대학
생명과학전공
Journal papers
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Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8
Title
Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8
Authors
Kim H.-T.
;
Lee M.-S.
;
Jeong Y.-M.
;
Ro H.
;
Kim D.-I.
;
Shin Y.-H.
;
Kim J.-E.
;
Hwang K.-S.
;
Choi J.-H.
;
Bahn M.
;
Lee J.-J.
;
Lee S.H.
;
Bae Y.-K.
;
Lee J.-S.
;
Choi J.-K.
;
Kim N.-S.
;
Yeo C.-Y.
;
Kim C.-H.
Ewha Authors
여창열
SCOPUS Author ID
여창열
Issue Date
2017
Journal Title
Scientific Reports
ISSN
2045-2322
Citation
Scientific Reports vol. 7, no. 1
Publisher
Nature Publishing Group
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Wnt signaling controls critical developmental processes including tissue/body patterning. Here we report the identification of a novel regulator of Wnt signaling, OTTOGI (OTG), isolated from a large-scale expression screening of human cDNAs in zebrafish embryos. Overexpression of OTG in zebrafish embryos caused dorso-Anteriorized phenotype, inhibited the expression of Wnt target genes, and prevented nuclear accumulation of β-catenin. Conversely, knockdown of zebrafish otg using specific antisense morpholino promoted nuclear accumulation of β-catenin and caused ventralization. However, OTG failed to rescue headless-like phenotype induced by inhibition of GSK-3β activity, suggesting that OTG acts upstream of GSK-3β. OTG bound specifically to Frizzled8 (Fz8) receptor and caused retention of Fz8 in the endoplasmic reticulum possibly by preventing N-linked glycosylation of Fz8. Taken together, our data indicate that OTG functions as a novel negative regulator of Wnt signaling during development by the modulation of cell surface expression of Fz receptor. © 2017 The Author(s).
DOI
10.1038/s41598-017-13429-6
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