Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 여창열 | * |
dc.date.accessioned | 2017-12-27T16:30:53Z | - |
dc.date.available | 2017-12-27T16:30:53Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-21503 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239384 | - |
dc.description.abstract | Wnt signaling controls critical developmental processes including tissue/body patterning. Here we report the identification of a novel regulator of Wnt signaling, OTTOGI (OTG), isolated from a large-scale expression screening of human cDNAs in zebrafish embryos. Overexpression of OTG in zebrafish embryos caused dorso-Anteriorized phenotype, inhibited the expression of Wnt target genes, and prevented nuclear accumulation of β-catenin. Conversely, knockdown of zebrafish otg using specific antisense morpholino promoted nuclear accumulation of β-catenin and caused ventralization. However, OTG failed to rescue headless-like phenotype induced by inhibition of GSK-3β activity, suggesting that OTG acts upstream of GSK-3β. OTG bound specifically to Frizzled8 (Fz8) receptor and caused retention of Fz8 in the endoplasmic reticulum possibly by preventing N-linked glycosylation of Fz8. Taken together, our data indicate that OTG functions as a novel negative regulator of Wnt signaling during development by the modulation of cell surface expression of Fz receptor. © 2017 The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Publishing Group | * |
dc.title | Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8 | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 7 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-017-13429-6 | * |
dc.identifier.wosid | WOS:000413048000089 | * |
dc.identifier.scopusid | 2-s2.0-85031779920 | * |
dc.author.google | Kim H.-T. | * |
dc.author.google | Lee M.-S. | * |
dc.author.google | Jeong Y.-M. | * |
dc.author.google | Ro H. | * |
dc.author.google | Kim D.-I. | * |
dc.author.google | Shin Y.-H. | * |
dc.author.google | Kim J.-E. | * |
dc.author.google | Hwang K.-S. | * |
dc.author.google | Choi J.-H. | * |
dc.author.google | Bahn M. | * |
dc.author.google | Lee J.-J. | * |
dc.author.google | Lee S.H. | * |
dc.author.google | Bae Y.-K. | * |
dc.author.google | Lee J.-S. | * |
dc.author.google | Choi J.-K. | * |
dc.author.google | Kim N.-S. | * |
dc.author.google | Yeo C.-Y. | * |
dc.author.google | Kim C.-H. | * |
dc.contributor.scopusid | 여창열(7102545519) | * |
dc.date.modifydate | 20240419142344 | * |