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Antinociceptive synergy between the cannabinoid receptor agonist WIN 55,212-2 and bupivacaine in the rat formalin test
- Title
- Antinociceptive synergy between the cannabinoid receptor agonist WIN 55,212-2 and bupivacaine in the rat formalin test
- Authors
- Kang S.; Kim C.H.; Lee H.; Kim D.Y.; Han J.I.; Chung R.K.; Lee G.Y.
- Ewha Authors
- 이귀용; 김치효; 정락경; 한종인; 김동연; 이희승
- SCOPUS Author ID
- 이귀용; 김치효; 정락경; 한종인; 김동연; 이희승
- Issue Date
- 2007
- Journal Title
- Anesthesia and Analgesia
- ISSN
- 0003-2999
- Citation
- Anesthesia and Analgesia vol. 104, no. 3, pp. 719 - 725
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- BACKGROUND: The analgesic interaction between cannabinoids and local anesthetics has not been investigated. We sought to determine the nature of the interaction between the intrathecal cannabinoid receptor agonist (WIN 55,212-2) and bupivacaine using the formalin test. METHODS: Lumbar intrathecal catheters were implanted in male Sprague-Dawley rats. After intrathecal administration of WIN 55,212-2, bupivacaine, or their combination, 50 μL of 5% formalin was injected subcutaneously into the hindpaw. Dose-response curves were established and the respective ED50 (50% effective dose) values were determined for each agent alone. Fixed-ratio combinations of WIN 55,212-2 and bupivacaine were tested for combined antinociceptive effects in the formalin test and an isobolographic analysis was performed to characterize the pharmacologic interaction of both drugs. RESULTS: Intrathecally administered WIN 55,212-2, bupivacaine, or their combination produced a dose-dependent decrease in the number of flinches during Phase 1 and 2 of the formalin test. Isobolographic analysis revealed a synergistic interaction between intrathecal WIN 55,212-2 and bupivacaine in both phases of the formalin test. In combination, the ED50 value was significantly smaller than the theoretical additive value (P < 0.05). CONCLUSIONS: These results demonstrate that intrathecally coadministered WIN 55,212-2 and bupivacaine provide synergistic antinociceptive interaction in both phases of the formalin test. © 2007 by International Anesthesia Research Society.
- DOI
- 10.1213/01.ane.0000255291.38637.26
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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