Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이귀용 | * |
dc.contributor.author | 김치효 | * |
dc.contributor.author | 정락경 | * |
dc.contributor.author | 한종인 | * |
dc.contributor.author | 김동연 | * |
dc.contributor.author | 이희승 | * |
dc.date.accessioned | 2017-02-15T08:02:01Z | - |
dc.date.available | 2017-02-15T08:02:01Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0003-2999 | * |
dc.identifier.other | OAK-3847 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234256 | - |
dc.description.abstract | BACKGROUND: The analgesic interaction between cannabinoids and local anesthetics has not been investigated. We sought to determine the nature of the interaction between the intrathecal cannabinoid receptor agonist (WIN 55,212-2) and bupivacaine using the formalin test. METHODS: Lumbar intrathecal catheters were implanted in male Sprague-Dawley rats. After intrathecal administration of WIN 55,212-2, bupivacaine, or their combination, 50 μL of 5% formalin was injected subcutaneously into the hindpaw. Dose-response curves were established and the respective ED50 (50% effective dose) values were determined for each agent alone. Fixed-ratio combinations of WIN 55,212-2 and bupivacaine were tested for combined antinociceptive effects in the formalin test and an isobolographic analysis was performed to characterize the pharmacologic interaction of both drugs. RESULTS: Intrathecally administered WIN 55,212-2, bupivacaine, or their combination produced a dose-dependent decrease in the number of flinches during Phase 1 and 2 of the formalin test. Isobolographic analysis revealed a synergistic interaction between intrathecal WIN 55,212-2 and bupivacaine in both phases of the formalin test. In combination, the ED50 value was significantly smaller than the theoretical additive value (P < 0.05). CONCLUSIONS: These results demonstrate that intrathecally coadministered WIN 55,212-2 and bupivacaine provide synergistic antinociceptive interaction in both phases of the formalin test. © 2007 by International Anesthesia Research Society. | * |
dc.language | English | * |
dc.title | Antinociceptive synergy between the cannabinoid receptor agonist WIN 55,212-2 and bupivacaine in the rat formalin test | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 104 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 719 | * |
dc.relation.lastpage | 725 | * |
dc.relation.journaltitle | Anesthesia and Analgesia | * |
dc.identifier.doi | 10.1213/01.ane.0000255291.38637.26 | * |
dc.identifier.wosid | WOS:000244431500050 | * |
dc.identifier.scopusid | 2-s2.0-33847231287 | * |
dc.author.google | Kang S. | * |
dc.author.google | Kim C.H. | * |
dc.author.google | Lee H. | * |
dc.author.google | Kim D.Y. | * |
dc.author.google | Han J.I. | * |
dc.author.google | Chung R.K. | * |
dc.author.google | Lee G.Y. | * |
dc.contributor.scopusid | 이귀용(15925249600) | * |
dc.contributor.scopusid | 김치효(36059166000) | * |
dc.contributor.scopusid | 정락경(15925032500) | * |
dc.contributor.scopusid | 한종인(57206610922) | * |
dc.contributor.scopusid | 김동연(55511080500) | * |
dc.contributor.scopusid | 이희승(57216677572) | * |
dc.date.modifydate | 20240415132314 | * |