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dc.contributor.author이귀용-
dc.contributor.author김치효-
dc.contributor.author정락경-
dc.contributor.author한종인-
dc.contributor.author김동연-
dc.contributor.author이희승-
dc.date.accessioned2017-02-15T08:02:01Z-
dc.date.available2017-02-15T08:02:01Z-
dc.date.issued2007-
dc.identifier.issn0003-2999-
dc.identifier.otherOAK-3847-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/234256-
dc.description.abstractBACKGROUND: The analgesic interaction between cannabinoids and local anesthetics has not been investigated. We sought to determine the nature of the interaction between the intrathecal cannabinoid receptor agonist (WIN 55,212-2) and bupivacaine using the formalin test. METHODS: Lumbar intrathecal catheters were implanted in male Sprague-Dawley rats. After intrathecal administration of WIN 55,212-2, bupivacaine, or their combination, 50 μL of 5% formalin was injected subcutaneously into the hindpaw. Dose-response curves were established and the respective ED50 (50% effective dose) values were determined for each agent alone. Fixed-ratio combinations of WIN 55,212-2 and bupivacaine were tested for combined antinociceptive effects in the formalin test and an isobolographic analysis was performed to characterize the pharmacologic interaction of both drugs. RESULTS: Intrathecally administered WIN 55,212-2, bupivacaine, or their combination produced a dose-dependent decrease in the number of flinches during Phase 1 and 2 of the formalin test. Isobolographic analysis revealed a synergistic interaction between intrathecal WIN 55,212-2 and bupivacaine in both phases of the formalin test. In combination, the ED50 value was significantly smaller than the theoretical additive value (P < 0.05). CONCLUSIONS: These results demonstrate that intrathecally coadministered WIN 55,212-2 and bupivacaine provide synergistic antinociceptive interaction in both phases of the formalin test. © 2007 by International Anesthesia Research Society.-
dc.languageEnglish-
dc.titleAntinociceptive synergy between the cannabinoid receptor agonist WIN 55,212-2 and bupivacaine in the rat formalin test-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume104-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage719-
dc.relation.lastpage725-
dc.relation.journaltitleAnesthesia and Analgesia-
dc.identifier.doi10.1213/01.ane.0000255291.38637.26-
dc.identifier.wosidWOS:000244431500050-
dc.identifier.scopusid2-s2.0-33847231287-
dc.author.googleKang S.-
dc.author.googleKim C.H.-
dc.author.googleLee H.-
dc.author.googleKim D.Y.-
dc.author.googleHan J.I.-
dc.author.googleChung R.K.-
dc.author.googleLee G.Y.-
dc.contributor.scopusid이귀용(15925249600)-
dc.contributor.scopusid김치효(36059166000)-
dc.contributor.scopusid정락경(15925032500)-
dc.contributor.scopusid한종인(55590477300)-
dc.contributor.scopusid김동연(55511080500)-
dc.contributor.scopusid이희승(11839935100)-
dc.date.modifydate20200901081003-
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의과대학 > 의학과 > Journal papers
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