Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이은경 | * |
dc.date.accessioned | 2016-08-29T12:08:58Z | - |
dc.date.available | 2016-08-29T12:08:58Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0306-5251 | * |
dc.identifier.issn | 1365-2125 | * |
dc.identifier.other | OAK-18862 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231664 | - |
dc.description.abstract | AimsThis study characterized the pharmacokinetics of ramosetron and compared prophylactic anti-emetic efficacy with that of ondansetron in a large population. MethodsFifty-eight patients consented to the pharmacokinetic analysis and were assigned randomly to receive 0.3, 0.45 or 0.6mg ramosetron after induction of anaesthesia. Blood samples were acquired at preset intervals. Non-compartmental and population pharmacokinetic analyses were performed. In total, 1102 patients consented to the evaluation of prophylactic anti-emetic efficacy and were allocated randomly to receive 0.3mg ramosetron or 4mg ondansetron at the end of surgery. An additional 16mg ondansetron were mixed in the intravenous patient-controlled analgesia pump of the ondansetron group. Post-operative nausea and vomiting (PONV) were evaluated 6, 24 and 48h post-operatively using the Rhodes index of nausea, vomiting and retching (RINVR). Administration of rescue anti-emetics and adverse events were evaluated. ResultsThe pharmacokinetic parameter estimates were V-1 (l)=5.12, V-2 (l)=108, CL (lmin(-1))=0.08+(59age(-1))x0.09, Q (lmin(-1))=1.42. The incidences of PONV in the ramosetron and ondansetron groups were 77 (13.9%) and 113 (20.6%) and 44 (7.9%) and 66 (12.0%) at 24 and 48h post-operatively, respectively (P=0.004, 0.030). RINVR was significantly lower in the ramosetron than the ondansetron group 24 and 48h post-operatively (P=0.003, 0.025). Use of rescue anti-emetics and incidence of adverse events were comparable. ConclusionsA two compartment mammillary model was used to describe ramosetron pharmacokinetics. Prophylactic anti-emetic efficacy of ramosetron was significantly better 24 and 48h post-operatively than that of ondansetron, particularly when the Apfel score was3. | * |
dc.language | English | * |
dc.publisher | WILEY-BLACKWELL | * |
dc.subject | anti-emetics | * |
dc.subject | pharmacokinetics | * |
dc.subject | post-operative nausea and vomiting | * |
dc.subject | ramosetron | * |
dc.title | Population pharmacokinetics and prophylactic anti-emetic efficacy of ramosetron in surgical patients | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 82 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 762 | * |
dc.relation.lastpage | 772 | * |
dc.relation.journaltitle | BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | * |
dc.identifier.doi | 10.1111/bcp.13010 | * |
dc.identifier.wosid | WOS:000382509900015 | * |
dc.identifier.scopusid | 2-s2.0-84983006870 | * |
dc.author.google | Lee, Yong-Hun | * |
dc.author.google | Seo, Jae-Hyeon | * |
dc.author.google | Min, Kyung-Tae | * |
dc.author.google | Lim, Young-Jin | * |
dc.author.google | Jeong, Seong-Wook | * |
dc.author.google | Lee, Eun-Kyung | * |
dc.author.google | Choi, Byung-Moon | * |
dc.author.google | Noh, Gyu-Jeong | * |
dc.contributor.scopusid | 이은경(57188770360;57217075385) | * |
dc.date.modifydate | 20240123125059 | * |