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A FoxO1-dependent, but NRF2-independent induction of heme oxygenase-1 during muscle atrophy

Title
A FoxO1-dependent, but NRF2-independent induction of heme oxygenase-1 during muscle atrophy
Authors
Kang J.Jeong M.G.Oh S.Jang E.J.Kim H.K.Hwang E.S.
Ewha Authors
황은숙
SCOPUS Author ID
황은숙scopus
Issue Date
2014
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
FEBS Letters vol. 588, no. 1, pp. 79 - 85
Keywords
FoxO1MAFbxMuRF1Nerve injuryNRF2
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Skeletal muscle plays key roles in metabolic homeostasis. Loss of muscle mass, called muscle atrophy exacerbates disease-associated metabolic perturbations. In this study, we characterized the molecular functions and mechanisms underlying regulation of skeletal muscle atrophy induced by denervation. Denervation significantly increased the expression of heme oxygenase-1 (HO-1) and atrogenes in skeletal muscle. Forkhead box protein O1 (FoxO1) drastically increased in atrophied muscle and selectively stimulated HO-1 gene transcription through direct DNA binding. Lack of HO-1 substantially attenuated muscle atrophy, whereas HO-1 overexpression caused muscle damage in vitro and in vivo. Collectively, HO-1 induced by FoxO1 may cause skeletal muscle atrophy. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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DOI
10.1016/j.febslet.2013.11.009
Appears in Collections:
약학대학 > 약학과 > Journal papers
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