Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황은숙 | * |
dc.date.accessioned | 2016-08-28T11:08:26Z | - |
dc.date.available | 2016-08-28T11:08:26Z | - |
dc.date.issued | 2014 | * |
dc.identifier.issn | 0014-5793 | * |
dc.identifier.other | OAK-10865 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/227381 | - |
dc.description.abstract | Skeletal muscle plays key roles in metabolic homeostasis. Loss of muscle mass, called muscle atrophy exacerbates disease-associated metabolic perturbations. In this study, we characterized the molecular functions and mechanisms underlying regulation of skeletal muscle atrophy induced by denervation. Denervation significantly increased the expression of heme oxygenase-1 (HO-1) and atrogenes in skeletal muscle. Forkhead box protein O1 (FoxO1) drastically increased in atrophied muscle and selectively stimulated HO-1 gene transcription through direct DNA binding. Lack of HO-1 substantially attenuated muscle atrophy, whereas HO-1 overexpression caused muscle damage in vitro and in vivo. Collectively, HO-1 induced by FoxO1 may cause skeletal muscle atrophy. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.subject | FoxO1 | * |
dc.subject | MAFbx | * |
dc.subject | MuRF1 | * |
dc.subject | Nerve injury | * |
dc.subject | NRF2 | * |
dc.title | A FoxO1-dependent, but NRF2-independent induction of heme oxygenase-1 during muscle atrophy | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 588 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 79 | * |
dc.relation.lastpage | 85 | * |
dc.relation.journaltitle | FEBS Letters | * |
dc.identifier.doi | 10.1016/j.febslet.2013.11.009 | * |
dc.identifier.wosid | WOS:000329058400014 | * |
dc.identifier.scopusid | 2-s2.0-84891040549 | * |
dc.author.google | Kang J. | * |
dc.author.google | Jeong M.G. | * |
dc.author.google | Oh S. | * |
dc.author.google | Jang E.J. | * |
dc.author.google | Kim H.K. | * |
dc.author.google | Hwang E.S. | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.date.modifydate | 20240123102458 | * |