Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이은경 | * |
dc.date.accessioned | 2016-08-28T10:08:26Z | - |
dc.date.available | 2016-08-28T10:08:26Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0140-7783 | * |
dc.identifier.other | OAK-8974 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222811 | - |
dc.description.abstract | This study aimed at assessing the predictive performance of a target-controlled infusion (TCI) system, which incorporates canine PK-PD models for microemulsion and long-chain triglyceride emulsion (LCT) propofol and at investigating time independency of propofol effect on the observed electroencephalographic approximate entropy (ApEn) in TCI. Using a crossover design with a 7-day washout period, 28 healthy beagle dogs were randomized to receive TCI of both formulations in a stepwise or constant manner. Plasma propofol concentrations and ApEn were measured at preset intervals. Pooled biases, inaccuracies, divergences, and wobbles in pharmacokinetic and pharmacodynamic predictions were 2.1% (95% CI: -0.8 to 4.9), 18.1% (15.6-20.5), 1.9%/h, 7.3% (5.4-9.3), and -0.5% (-2.6 to 1.6), 8.7% (7.3-10.1), 2.5%/h, 6.0% (4.1-7.2) for microemulsion propofol, and -9.3% (-11.6 to -6.9), 20.1% (18.2-22.0), 5.1%/h, 7.6% (6.1-9.1) and 5.6% (4.1-7.1), 8.0% (6.9-9.3), 4.7%/h, 4.1% (3.1-5.1) for LCT propofol. Observed ApEn values over time were statistically not different across all time points in a TCI with constant manner. Canine PK-PD model of microemulsion propofol showed good predictive performances. Propofol effect (ApEn) was time independent as long as time is allowed for equilibration. © 2011 Blackwell Publishing Ltd. | * |
dc.language | English | * |
dc.title | External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long-chain triglyceride emulsion propofol in beagle dogs | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 35 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 329 | * |
dc.relation.lastpage | 341 | * |
dc.relation.journaltitle | Journal of Veterinary Pharmacology and Therapeutics | * |
dc.identifier.doi | 10.1111/j.1365-2885.2011.01321.x | * |
dc.identifier.wosid | WOS:000306006100003 | * |
dc.identifier.scopusid | 2-s2.0-84863553396 | * |
dc.author.google | Lee S.-H. | * |
dc.author.google | Park H.-W. | * |
dc.author.google | Kim M.-J. | * |
dc.author.google | Noh M.-H. | * |
dc.author.google | Yoon H.-S. | * |
dc.author.google | Choi B.-M. | * |
dc.author.google | Lee E.-K. | * |
dc.author.google | Noh G.-J. | * |
dc.contributor.scopusid | 이은경(57188770360;57217075385) | * |
dc.date.modifydate | 20240123125059 | * |