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Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells
- Title
- Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells
- Authors
- Park, Minhwa; Kim, Yu-Hee; Ryu, Jung-Hwa; Woo, So-Youn; Ryu, Kyung-Ha
- Ewha Authors
- 유경하; 우소연; 김유희
- SCOPUS Author ID
- 유경하; 우소연; 김유희
- Issue Date
- 2015
- Journal Title
- STEM CELLS INTERNATIONAL
- ISSN
- 1687-966X
1687-9678
- Citation
- STEM CELLS INTERNATIONAL
- Publisher
- HINDAWI PUBLISHING CORPORATION
- Indexed
- SCIE
- Document Type
- Article
- Abstract
- Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation and maturation of bone-marrow-(BM-) derived monocytes into DCs and we found suppressive effect of T-MSCs on DCs via direct contact as well as soluble mediators. Moreover, T cell proliferation, normally increased in the presence of DCs, was inhibited by T-MSCs. Differentiation of CD4(+) T cell subsets by the DC-T cell interaction also was inhibited by T-MSCs. The soluble mediators suppressed by T-MSCs were granulocyte-macrophage colonystimulating factor (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Taken together, T-MSCs exert immune modulatory function via suppression of the differentiation, maturation, and function of BM-derived DCs. Our data suggests that T-MSCs could be used as a novel source of stem cell therapy as immune modulators.
- DOI
- 10.1155/2015/106540
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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