Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 우소연 | * |
dc.contributor.author | 김유희 | * |
dc.date.accessioned | 2016-08-27T04:08:15Z | - |
dc.date.available | 2016-08-27T04:08:15Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1687-966X | * |
dc.identifier.issn | 1687-9678 | * |
dc.identifier.other | OAK-14646 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217060 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation and maturation of bone-marrow-(BM-) derived monocytes into DCs and we found suppressive effect of T-MSCs on DCs via direct contact as well as soluble mediators. Moreover, T cell proliferation, normally increased in the presence of DCs, was inhibited by T-MSCs. Differentiation of CD4(+) T cell subsets by the DC-T cell interaction also was inhibited by T-MSCs. The soluble mediators suppressed by T-MSCs were granulocyte-macrophage colonystimulating factor (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Taken together, T-MSCs exert immune modulatory function via suppression of the differentiation, maturation, and function of BM-derived DCs. Our data suggests that T-MSCs could be used as a novel source of stem cell therapy as immune modulators. | * |
dc.language | English | * |
dc.publisher | HINDAWI PUBLISHING CORPORATION | * |
dc.title | Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells | * |
dc.type | Article | * |
dc.relation.index | SCIE | * |
dc.relation.journaltitle | STEM CELLS INTERNATIONAL | * |
dc.identifier.doi | 10.1155/2015/106540 | * |
dc.identifier.wosid | WOS:000350665200001 | * |
dc.author.google | Park, Minhwa | * |
dc.author.google | Kim, Yu-Hee | * |
dc.author.google | Ryu, Jung-Hwa | * |
dc.author.google | Woo, So-Youn | * |
dc.author.google | Ryu, Kyung-Ha | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 김유희(15764983100) | * |
dc.date.modifydate | 20240118130224 | * |