Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장유정 | - |
dc.creator | 장유정 | - |
dc.date.accessioned | 2016-08-25T04:08:11Z | - |
dc.date.available | 2016-08-25T04:08:11Z | - |
dc.date.issued | 2005 | - |
dc.identifier.other | OAK-000000012043 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/178981 | - |
dc.identifier.uri | http://dcollection.ewha.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000012043 | - |
dc.description.abstract | 4(5)-(6-Alkylpyridin-2-yl)imidazoles 계열의 신규화합물을 합성하고 이들의 ALK5 저해능을 luciferase reporter을 이용하여 측정하였다. 가장 강력한 저해능을 보인 화합물 7e는 0.1 μM 농도에서 p3TP-Luciferase, SBE-Luciferase, ARE-Luciferase를 각각 93%, 75%, 87%을 저해하며, 같은 농도에서, 각각 31%, 32%, 0%의 저해능을 보인 영국 GSK제약 회사의 SB-431542보다 우수한 화합물임을 입증하였다.;A series of 4(5)-(6-alkylpyridin-2-yl)imidazoles have been synthesized and evaluated for their ALK5 inhibitory activity in the luciferase reporter assays. Compound 7e showed the most significant ALK5 inhibition (p3TP-Luciferase, 93%; SBE-Luciferase, 75%; ARE-Luciferase, 87%) at a concentration of 0.1 μM that is much higher than that of SB-431542 (p3TP-Luciferase, 31%; SBE-Luciferase, 32%; ARE-Luciferase, 0%). | - |
dc.description.tableofcontents | Abstract = ⅷ Ⅰ. Introduction = 1 Ⅱ. Results and Discussion = 6 Ⅲ. Conclusion = 16 Ⅳ. Experimental Section = 17 Ⅴ. References = 36 국문초록 = 41 | - |
dc.format | application/pdf | - |
dc.format.extent | 688927 bytes | - |
dc.language | eng | - |
dc.publisher | 이화여자대학교 대학원 | - |
dc.title | Synthesis and Biological Evaluation of Novel 4(5)-(6-alkylpyridin-2-yl)imidazoles as Inhibitors of Transforming Growth Factor β1 Type Ⅰ Receptor | - |
dc.type | Master's Thesis | - |
dc.creator.othername | Jang, Yoo-Jeung | - |
dc.format.page | ⅷ, 44 p. | - |
dc.identifier.thesisdegree | Master | - |
dc.identifier.major | 대학원 약학과 | - |
dc.date.awarded | 2006. 2 | - |