Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이수영 | - |
dc.contributor.author | 김태수 | - |
dc.contributor.author | 박진희 | - |
dc.contributor.author | 김수리 | - |
dc.date.accessioned | 2024-08-26T16:31:09Z | - |
dc.date.available | 2024-08-26T16:31:09Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 2095-4700 | - |
dc.identifier.other | OAK-35773 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/269368 | - |
dc.description.abstract | Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border. However, the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely unknown. Here, we show with GeneChip analysis that RUN and FYVE domain-containing protein 4 (RUFY4) is strongly upregulated during osteoclastogenesis. Mice lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in vivo. Furthermore, deleting Rufy4 did not affect osteoclast differentiation, but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes, their trafficking to the membrane, and their secretion of cathepsin K into the extracellular space. Mechanistically, RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary lysosomes. Consequently, Rufy4-deficient mice were highly protected from lipopolysaccharide- and ovariectomy-induced bone loss. Thus, RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis. © The Author(s) 2024. | - |
dc.description.sponsorship | Springer Nature | - |
dc.language | English | - |
dc.title | RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 12 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Bone Research | - |
dc.identifier.doi | 10.1038/s41413-024-00326-8 | - |
dc.identifier.wosid | WOS:001222589000001 | - |
dc.identifier.scopusid | 2-s2.0-85192975139 | - |
dc.author.google | Kim | - |
dc.author.google | Minhee | - |
dc.author.google | Park | - |
dc.author.google | Jin Hee | - |
dc.author.google | Go | - |
dc.author.google | Miyeon | - |
dc.author.google | Lee | - |
dc.author.google | Nawon | - |
dc.author.google | Seo | - |
dc.author.google | Jeongin | - |
dc.author.google | Hana | - |
dc.author.google | Doyong | - |
dc.author.google | Ha | - |
dc.author.google | Hyunil | - |
dc.author.google | Taesoo | - |
dc.author.google | Jeong | - |
dc.author.google | Myeong Seon | - |
dc.author.google | Suree | - |
dc.author.google | Han Sung | - |
dc.author.google | Kang | - |
dc.author.google | Dongmin | - |
dc.author.google | Shim | - |
dc.author.google | Hyunbo | - |
dc.author.google | Soo Young | - |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | - |
dc.contributor.scopusid | 김태수(57223774706) | - |
dc.contributor.scopusid | 박진희(57196405683;56593418700) | - |
dc.date.modifydate | 20240826132832 | - |