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의과대학
의학과
Journal papers
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A Case of Nivolumab-Induced Bullous Pemphigoid in a Patient with Metastatic Breast Cancer
Title
A Case of Nivolumab-Induced Bullous Pemphigoid in a Patient with Metastatic Breast Cancer
Authors
Lee
;
Jin Ju
;
Choi
;
Yoon Jin
;
You Won
;
Roh
;
Joo Young
;
Hae Young
;
Byun
;
Ji Yeon
Ewha Authors
최혜영
;
최유원
;
변지연
;
노주영
SCOPUS Author ID
최혜영
; 최유원
; 변지연
Issue Date
2024
Journal Title
Korean Journal of Dermatology
ISSN
4944-4739
Citation
Korean Journal of Dermatology vol. 62, no. 5, pp. 299 - 302
Keywords
Bullous pemphigoid
;
Immunotherapy
;
Nivolumab
Indexed
SCOPUS
Document Type
Article
Abstract
Nivolumab is a checkpoint inhibitor monoclonal antibody, designed to interact with the programmed death cell receptor-1, preventing the inhibitory signaling on cytotoxic T cells. Immune checkpoint inhibitors can lead to severe cutaneous immune-related adverse events (irAEs). A 54-year-old female with a breast cancer metastasis was referred to our clinic due to diffuse cutaneous lesions of crusted erythematous patches and multiple blisters for 2 weeks. Five months before presentation, she started nivolumab/eribulin immunotherapy. Skin biopsy showed subepidermal blistering with perivascular lymphohistiocytic infiltration with eosinophils. Direct immunofluorescence showed linear deposition of immunoglobulin G and C3 along the dermoepidermal junction, consistent with bullous pemphigoid. Temporal relationship between initiation of nivolumab and skin lesion suggested the diagnosis of nivolumab-induced bullous pemphigoid. Dermatologic toxicity is the most common irAEs associated with nivolumab, but nivolumab-induced bullous pemphigoid is rare. Given the widespread use of immunotherapy, it is important to document this case to develop proper management strategies. © 2024 Korean Dermatological Association. All rights reserved.
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