Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최혜영 | - |
dc.contributor.author | 최유원 | - |
dc.contributor.author | 변지연 | - |
dc.contributor.author | 노주영 | - |
dc.date.accessioned | 2024-08-26T16:31:02Z | - |
dc.date.available | 2024-08-26T16:31:02Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 4944-4739 | - |
dc.identifier.other | OAK-35827 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/269324 | - |
dc.description.abstract | Nivolumab is a checkpoint inhibitor monoclonal antibody, designed to interact with the programmed death cell receptor-1, preventing the inhibitory signaling on cytotoxic T cells. Immune checkpoint inhibitors can lead to severe cutaneous immune-related adverse events (irAEs). A 54-year-old female with a breast cancer metastasis was referred to our clinic due to diffuse cutaneous lesions of crusted erythematous patches and multiple blisters for 2 weeks. Five months before presentation, she started nivolumab/eribulin immunotherapy. Skin biopsy showed subepidermal blistering with perivascular lymphohistiocytic infiltration with eosinophils. Direct immunofluorescence showed linear deposition of immunoglobulin G and C3 along the dermoepidermal junction, consistent with bullous pemphigoid. Temporal relationship between initiation of nivolumab and skin lesion suggested the diagnosis of nivolumab-induced bullous pemphigoid. Dermatologic toxicity is the most common irAEs associated with nivolumab, but nivolumab-induced bullous pemphigoid is rare. Given the widespread use of immunotherapy, it is important to document this case to develop proper management strategies. © 2024 Korean Dermatological Association. All rights reserved. | - |
dc.description.sponsorship | Korean Dermatological Association | - |
dc.language | English | - |
dc.subject | Bullous pemphigoid | - |
dc.subject | Immunotherapy | - |
dc.subject | Nivolumab | - |
dc.title | A Case of Nivolumab-Induced Bullous Pemphigoid in a Patient with Metastatic Breast Cancer | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 62 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 299 | - |
dc.relation.lastpage | 302 | - |
dc.relation.journaltitle | Korean Journal of Dermatology | - |
dc.identifier.scopusid | 2-s2.0-85201012895 | - |
dc.author.google | Lee | - |
dc.author.google | Jin Ju | - |
dc.author.google | Choi | - |
dc.author.google | Yoon Jin | - |
dc.author.google | You Won | - |
dc.author.google | Roh | - |
dc.author.google | Joo Young | - |
dc.author.google | Hae Young | - |
dc.author.google | Byun | - |
dc.author.google | Ji Yeon | - |
dc.contributor.scopusid | 최혜영(55724363200) | - |
dc.contributor.scopusid | 최유원(7404777738) | - |
dc.contributor.scopusid | 변지연(15724462400) | - |
dc.date.modifydate | 20240826114927 | - |