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Comparison of Safety and Diagnostic Efficacy of Iohexo240 mgI/mL, Iopamidol 250 mgI/mL, and Iodixanol 270 mgI/mL in Cerebral Angiography: A Prospective, Multicenter Study
- Title
- Comparison of Safety and Diagnostic Efficacy of Iohexo240 mgI/mL, Iopamidol 250 mgI/mL, and Iodixanol 270 mgI/mL in Cerebral Angiography: A Prospective, Multicenter Study
- Authors
- Baek; Jinwook; Jeong; Hae Woong; Heo; Young Jin; Yun; Suyoung; Kang; Myongjin; Kim; Byungjun; Eui Jong; Lim; Soo Mee; Lee; Boeun
- Ewha Authors
- 임수미; 이보은
- SCOPUS Author ID
- 임수미
![scopus](/images/layout/icon2.png)
- Issue Date
- 2024
- Journal Title
- Neurointervention
- ISSN
- 2093-9043
- Citation
- Neurointervention vol. 19, no. 2, pp. 82 - 91
- Keywords
- Cerebral angiography; Contrast media; Diagnostic imaging; Iohexol; Iopamidol; Safety
- Indexed
- SCOPUS; KCI
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Purpose: This multicenter prospective study aimed to evaluate the quality and diagnostic effectiveness of cerebral angiography images obtained using low-concentration iodinated contrast agents (iohexol 240 mgI/mL, iopamidol 250 mgI/mL, and iodixanol 270 mgI/mL) and to assess the safety thereof. The study addresses the need for safer contrast agent alternatives without compromising the diagnostic quality of identifying cerebrovascular disease. Materials and Methods: Conducted in 5 medical centers in South Korea, we enrolled patients aged 19 years or older who were referred for diagnostic cerebral angiography under non-emergency conditions, excluding those with specific health conditions and sensitivities. The study design included a prospective, observational approach with a 1-way analysis of variance (ANOVA) for sample size calculation, aiming for a total sample of 231 participants for adequate power. Image quality was evaluated using a 4-level scale by 2 independent, blind-ed radiologists, and adverse reactions were monitored both immediately and up to 7 days post-procedure. Statistical analysis involved 1-way ANOVA and Kruskal–Wallis tests to assess the image quality and safety profiles of the contrast agents. Results: Among 266 patients screened, 243 were included in the final analysis. The evaluation revealed no statistically significant differences in image quality among the 3 types of low-con-centration contrast agents. Adverse events were observed in 28.8% of patients, with 27.2% experiencing acute reactions, primarily mild reactions, and 3.3% experiencing delayed reactions. The overall safety profile showed no significant changes in vital signs or electrocardiogram readings before and after contrast agent injection. Conclusion: Using low-concentration iodinated contrast agents for cerebral angiography provides image quality comparable to that of conventional high-concentration agents, with no significant increase in adverse events, suggesting a safer alternative for patients. © 2024 Korean Society of Interventional Neuroradiology.
- DOI
- 10.5469/neuroint.2024.00129
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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