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Three new diterpenoids, plectalibertellenones A–C, isolated from endolichenic fungi Pseudoplectania sp. EL000327

Title
Three new diterpenoids, plectalibertellenones A–C, isolated from endolichenic fungi Pseudoplectania sp. EL000327
Authors
Jae-SeounYangIn-hoHyukjaeHangunNamSang-JipGamageChathurika D.B.SilvianiVelinaHurKimJeong-HyeonLeeChaeyoungChoiBo-MeeHillmanPrima F.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2024
Journal Title
Tetrahedron Letters
ISSN
4040-4039JCR Link
Citation
Tetrahedron Letters vol. 148
Keywords
CytotoxicityEndolichenic fungiMosher's methodNatural productsPlectalibertellenonePseudoplectania sp.
Indexed
SCOPUS scopus
Document Type
Article
Abstract
Three new pimarane diterpenoids, plectalibertellenones A−C (1–3), along with six known compounds, 9α-hydroxy-1,8(14),15-isopimaratrien-3,7,11-trione (4), 9α-hydroxy-1,8(14),15-isopimaratrien-3,11-dione (5), phomenone B (6), (−)-pestalotin (7), (+)-pestalotin (8), and 6-pentyl-4-methoxy-pyran-2-one (9) were isolated from the crude extract of an endolichenic fungus, Pseudoplectania sp. EL000327. The planar structures of metabolites 1–3 were elucidated using UV, mass spectrometry (MS), and nuclear magnetic resonance (NMR) spectroscopic data. The relative and absolute configurations of 1–3 were deduced from an interpretation of circular dichroism (CD) spectroscopic data, application of an advanced Mosher's method, DP4+ calculations, and combination of NMR spectroscopic methods. Compounds 1–9 did not display any significant anti-bacterial activity; however, compounds 1–4 were cytotoxic to Caco2 cells, with IC50 values 54.8, 80.7, 76.4, and 19.6 µM, respectively. © 2024 Elsevier Ltd
DOI
10.1016/j.tetlet.2024.155227
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자연과학대학 > 화학·나노과학전공 > Journal papers
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