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An ER-targeted, Viscosity-sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway
- Title
- An ER-targeted, Viscosity-sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway
- Authors
- Zeng; Shuang; Wang; Yang; Chen; Kim; Heejeong; Liu; Xiaosheng; Jiang; Maojun; Yu; Yichu; Kafuti; Yves S.; Qixian; Jingyun; Peng; Xiaojun; Li; Haidong; Yoon; Juyoung
- Ewha Authors
- 윤주영
- SCOPUS Author ID
- 윤주영
![scopus](/images/layout/icon2.png)
- Issue Date
- 2024
- Journal Title
- Angewandte Chemie - International Edition
- ISSN
- 1433-7851
- Citation
- Angewandte Chemie - International Edition vol. 63, no. 9
- Keywords
- Endoplasmic Reticulum-Targeted; Nonalcoholic Fatty Liver Disease Visualization; Photodynamic Cancer Therapy; Pyroptosis; Viscosity-Sensitive
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- The concept of molecular design, integrating diagnostic and therapeutic functions, aligns with the general trend of modern medical advancement. Herein, we rationally designed the smart molecule ER-ZS for endoplasmic reticulum (ER)-targeted diagnosis and treatment in cell and animal models by combining hemicyanine dyes with ER-targeted functional groups (p-toluenesulfonamide). Owing to its ability to target the ER with a highly specific response to viscosity, ER-ZS demonstrated substantial fluorescence turn-on only after binding to the ER, independent of other physiological environments. In addition, ER-ZS, being a small molecule, allows for the diagnosis of nonalcoholic fatty liver disease (NAFLD) via liver imaging based on high ER stress. Importantly, ER-ZS is a type I photosensitizer, producing O2⋅− and ⋅OH under light irradiation. Thus, after irradiating for a certain period, the photodynamic therapy inflicted severe oxidative damage to the ER of tumor cells in hypoxic (2 % O2) conditions and activated the unique pyroptosis pathway, demonstrating excellent antitumor capacity in xenograft tumor models. Hence, the proposed strategy will likely shed new light on integrating molecular optics for NAFLD diagnosis and cancer therapy. © 2024 Wiley-VCH GmbH.
- DOI
- 10.1002/anie.202316487
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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